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Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells
(Impact Journals, 2015)
Galiellalactone (GL) is a fungal metabolite that presents antitumor activities on prostate cancer in vitro and in vivo. In this study we show that GL induced cell cycle arrest in G2/M phase, caspase-dependent apoptosis and ...
Neoflavonoids as Inhibitors of HIV-1 Replication by Targeting the Tat and NF-kB Pathways
(MDPI, 2017)
Twenty-eight neoflavonoids have been prepared and evaluated in vitro against HIV-1.
Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase reporter
gene. Inhibition of HIV ...
EHP-101 alleviates angiotensin II-induced fibrosis and inflammation in mice
(Elsevier, 2021)
Some cannabinoids showed anti-inflammatory and antifibrotic activities. EHP-101 is an oral lipidic formulation of the novel non-psychotropic cannabidiol aminoquinone VCE-004.8, which showed antifibrotic activity in murine ...
Betulinic Acid Hydroxamate is Neuroprotective and Induces Protein Phosphatase 2A-Dependent HIF-1α Stabilization and Post-transcriptional Dephosphorylation of Prolyl Hydrolase 2
(Springer, 2021)
Huntington’s disease (HD) is a neurodegenerative disorder characterized by unwanted choreatic movements, behavioral and psychiatric disturbances, and dementia. The activation of the hypoxic response pathway through the ...
Immunomodulatory and Inhibitory Effect of Immulina®, and Immunloges® in the Ig-E Mediated Activation of RBL-2H3 Cells. A New Role in Allergic Inflammatory Responses
(MDPI, 2018)
Immulina®, a high-molecular-weight polysaccharide extract from the cyanobacterium
Arthrospira platensis (Spirulina) is a potent activator of innate immune cells. On the other hand, it is
well documented that Spirulina ...
Cannabidiol and Other Cannabinoids in Demyelinating Diseases
(MDPI, 2021)
A growing body of preclinical evidence indicates that certain cannabinoids, including cannabidiol (CBD) and synthetic derivatives, may play a role in the myelinating processes and are promising small molecules to be developed ...
Detrimental Effect of Cannabidiol on the Early Onset of Diabetic Nephropathy in Male Mice
(MDPI, 2021)
Anti-inflammatory and antidiabetogenic properties have been ascribed to cannabidiol (CBD). CBD-based medicinal drugs have been approved for over a lustrum, and a boom in the commercialization of CBD products started in ...
3-Phenylcoumarins as Inhibitors of HIV-1 Replication
(MDPI, 2012)
We have synthesized fourteen 3-phenylcoumarin derivatives and evaluated their
anti-HIV activity. Antiviral activity was assessed on MT-2 cells infected with viral clones
carrying the luciferase gene as reporter. Inhibition ...
Neuroprotective Effects of Betulinic Acid Hydroxamate in Intraventricular Hemorrhage-Induced Brain Damage in Immature Rats
(MDPI, 2022)
Intraventricular hemorrhage (IVH) is an important cause of long-term disability in extremely preterm infants, with no current treatment. We aimed to study in an IVH model in immature rats the neuroprotective effect of ...