• In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/β-catenin activation 

      Martínez-Moreno, Julio M.; Muñoz-Castañeda, Juan R.; Herencia, Carmen; Montes de Oca, Addy; Estepa Nieto, José Carlos; Canalejo, Rocío; Rodríguez-Ortiz, Maria E.; Aguilera Tejero, Escolástico; Canalejo, Antonio; Rodríguez, Mariano; Almadén Peña, Yolanda; Pérez-Martínez, Pablo (American Journal of Physiology, 2012)
      The present study investigates the differential effect of two vitamin D receptor agonists, calcitriol and paricalcitol, on human aortic smooth muscle cells calcification in vitro. Human vascular smooth muscle cells were ...
    • Klotho/FGF23 and Wnt Signaling as Important Players in the Comorbidities Associated with Chronic Kidney Disease 

      Muñoz-Castañeda, Juan R.; Rodelo Haad, Cristian Roberto; Pendón-Ruiz de Mier, María V.; Martín-Malo, Alejandro; Santamaría, Rafael; Rodríguez, Mariano (MDPI, 2020)
      Fibroblast Growth Factor 23 (FGF23) and Klotho play an essential role in the regulation of mineral metabolism, and both are altered as a consequence of renal failure. FGF23 increases to augment phosphaturia, which prevents ...
    • Nuclear Translocation of b-Catenin during Mesenchymal Stem Cells Differentiation into Hepatocytes Is Associated with a Tumoral Phenotype 

      Herencia, Carmen; Martínez-Moreno, Julio M.; Herrera, Concepción; Corrales, Fernando J.; Santiago-Mora, Raquel; Espejo, Isabel; Barcos, Montserrat; Almadén Peña, Yolanda; Mata, Manuel de la; Rodríguez-Ariza, Antonio; Muñoz-Castañeda, Juan R. (Public Libray of Science (PLOS), 2012)
      Wnt/b-catenin pathway controls biochemical processes related to cell differentiation. In committed cells the alteration of this pathway has been associated with tumors as hepatocellular carcinoma or hepatoblastoma. The ...