A Mechanism-Based Sphingosine-1-phosphate Lyase Inhibitor

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Author
Pons, Guillem
Riba, Daniel
Casasampere, Mireia
Izquierdo, Eduardo
Abad, José Luis
Fabria, Gemma
Rodriguez Ortega, Pilar G.
López González, Juan J.
Montejo, Manuel
Casas, Josefina
Delgado, Antonio
Publisher
American Chemical Society
Date
2020
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Abstract
The synthesis of a series of vinylated analogues of sphingosine-1-phosphate together with their unambiguous configurational assignment by VCD methods is reported. Among them, compound RBM10-8 can irreversibly inhibit human sphingosine-1- phosphate lyase (hS1PL) while behaving also as an enzyme substrate. These findings, together with the postulated mechanism for S1PL activity, reinforce the role of RBM10-8 as a new mechanism-based hS1PL inhibitor.
URI
http://hdl.handle.net/10396/32247
Versión del Editor
https://doi.org/10.1021/acs.joc.9b02420
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