| dc.contributor.author | García-Martínez, Lucrecia | |
| dc.contributor.author | Gracia-Ahufinger, Irene | |
| dc.contributor.author | Machuca, Isabel | |
| dc.contributor.author | Cantisán, Sara | |
| dc.contributor.author | de la Fuente, Soraya | |
| dc.contributor.author | Pérez-Nadales, Elena | |
| dc.contributor.author | Vidal, Elisa | |
| dc.contributor.author | Rivero, Antonio | |
| dc.contributor.author | Rodríguez López, Fernando | |
| dc.contributor.author | Del Prado, José Ramón | |
| dc.contributor.author | Torre-Cisneros, J. | |
| dc.date.accessioned | 2025-02-03T06:59:43Z | |
| dc.date.available | 2025-02-03T06:59:43Z | |
| dc.date.issued | 2016 | |
| dc.identifier.uri | http://hdl.handle.net/10396/32304 | |
| dc.description | Embargado hasta 01/01/2100 | es_ES |
| dc.description.abstract | Background
There is little evidence of the impact of antimicrobial stewardship programmes on antimicrobial resistance.
Objectives
To study the efficacy and safety of a package of educational and interventional measures to optimize linezolid use and its impact on bacterial resistance.
Methods
A quasi-experimental study was designed and carried out before and after implementation of a stewardship programme in hospitalized patients with Gram-positive infections treated with linezolid.
Results
The intervention reduced linezolid consumption by 76%. The risk of linezolid-resistant CoNS isolates (OR = 0.37; 95% CI = 0.27–0.49; P < 0.001) and Enterococcus faecalis (OR = 0.44; 95% CI = 0.21–0.90; P = 0.03) during the intervention period was lower than in the pre-intervention period.
Conclusions
A programme to optimize linezolid use can contribute to reducing the resistance rate of CoNS and E. faecalis to this antibiotic. | es_ES |
| dc.format.mimetype | application/pdf | es_ES |
| dc.language.iso | eng | es_ES |
| dc.publisher | Oxford University Press | es_ES |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/ | es_ES |
| dc.source | García-Martínez, L., Gracia-Ahulfinger, I., Machuca, I., Cantisán, S., De la Fuente, S., Natera, C., Pérez-Nadales, E., Vidal, E., Rivero, A., Rodríguez-Lopez, F., Del Prado, J. R., & Torre-Cisneros, J. (2016). Impact of the PROVAUR stewardship programme on linezolid resistance in a tertiary university hospital: a before-and-after interventional study. Journal Of Antimicrobial Chemotherapy, 71(9), 2606-2611. https://doi.org/10.1093/jac/dkw179 | es_ES |
| dc.subject | antibioticsdrug resistance, microbialenterococcus faecalishospitals, universityknowledge acquisitionlinezolidantimicrobial stewardship | es_ES |
| dc.title | Impact of the PROVAUR stewardship programme on linezolid resistance in a tertiary university hospital: a before-and-after interventional study | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.relation.publisherversion | https://doi.org/10.1093/jac/dkw179 | es_ES |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
