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Role and regulation of the novel splicing variants sst5TMD4 and In1-ghrelin in breast cancer
(Universidad de Córdoba, UCOPress, 2016)
El cáncer, en sus múltiples formas, es uno de los mayores retos a los que se enfrenta la sociedad actual. Una de las mayores limitaciones en la investigación del cáncer es la gran heterogeneidad existente entre las diferentes ...
Functional role and therapeutic potential of the somatostatin and ghrelin systems and their splicing variants in prostate cancer
(Universidad de Córdoba, UCOPress, 2017)
El cáncer es una de las amenazas más serias y complejas para la salud de la población mundial1. En concreto, el cáncer de próstata es el segundo tipo de tumor solido más frecuente entre los hombres, y causa 300.000 muertes ...
Role of splicing process alterations in the appearance of endocrine-metabolic diseases and tumor pathologies
(Universidad de Córdoba, UCOPress, 2019)
Global human health is currently threatened by highly prevalent diseases such as obesity, diabetes and cancer. A common hallmark shared by these endocrine-metabolic and tumor diseases is the consistent alteration of the ...
Identification of novel cellular and/or molecular markers involved in the pharmacological response and contributions of splicing mechanisms in pituitary tumors
(Universidad de Córdoba, UCOPress, 2019)
Identification of novel molecular markers and contribution of splicing mechanisms in endocrine-related tumoral pathologies
(Universidad de Córdoba, UCOPress, 2020)
Cancer represents one of the main challenges for the human being, in that it encompasses some of the most severe and health-threatening pathologies worldwide. Although great efforts are being implemented and significant ...
Identification of novel endocrine-metabolic and splicing machinery factors with diagnostic, prognostic and/or therapeutic potential in prostate cancer
(Universidad de Córdoba, UCOPress, 2020)
Prostate cancer (PCa) is the tumor pathology with the highest incidence among men in developed countries and represents one of the main causes of cancer-related death in this group. Despite the advances achieved during the ...
Implication of the alternative splicing process in the development of hepatocelular carcinoma
(Universidad de Córdoba, UCOPress, 2021)
Liver cancer represents a complex and heterogeneous pathology that encompasses several types of malignant tumors with unfavorable characteristics and prognosis, including hepatocellular carcinoma or hepatocarcinoma (HCC). ...
Identification of Novel Markers and Molecular Mechanisms with Diagnostic, Prognostic, and Therapeutic Potential in Brain Tumors
(Universidad de Córdoba, UCOPress, 2022)
Primary brain tumors represent a highly variable and heterogeneous group of neoplasms (~150 different types) that includes non-malignant and malignant tumors. The most frequent malignant brain tumors are gliomas (representing ...
Unleashing the Diagnostic, Prognostic and Therapeutic Potential of the Neuronostatin/GPR107 System in Prostate Cancer
(MDPI, 2020)
Certain components of the somatostatin-system play relevant roles in Prostate Cancer (PCa), whose most aggressive phenotype (Castration-Resistant-PCa (CRPC)) remains lethal nowadays. However, neuronostatin and the G ...
Splicing Machinery is Dysregulated in Pituitary Neuroendocrine Tumors and is Associated with Aggressiveness Features
(MDPI, 2019)
Pituitary neuroendocrine tumors (PitNETs) constitute approximately 15% of all brain tumors, and most have a sporadic origin. Recent studies suggest that altered alternative splicing and, consequently, appearance of aberrant ...