Alhambra Expósito, María Rosa Ibáñez-Costa, Alejandro Moreno Moreno, Paloma Rivero-Cortés, Esther Vázquez Borrego, María del Carmen Blanco-Acevedo, Cristóbal Toledano-Delgado, Álvaro Lombardo Galera, María Sagrario Vallejo-Casas, Juan-Antonio Gahete Ortiz, Manuel D. Castaño, Justo P. Gálvez-Moreno, M. Ángeles Luque, Raúl M. 2026-02-26T09:59:03Z 2026-02-26T09:59:03Z 2018 http://hdl.handle.net/10396/35494 Acromegaly is a rare but severe disease, originated in 95% of cases by a growth hormone-secreting adenoma (somatotropinoma) in the pituitary. Magnetic resonance imaging (MRI) is a non-invasive technique used for the diagnosis and prognosis of pituitary tumours. The aim of this study was to determine whether the use of T2-weighted signal intensity at MRI could help to improve the characterisation of somatotropinomas, by analysing its relationship with clinical/molecular features. An observational study was implemented in a cohort of 22 patients (mean age = 42.1 ± 17.2 years; 59% women; 95% size>10 mm). Suprasellar-extended somatotropinomas presented larger diameters vs. non-extended tumours. T2-imaging revealed that 59% of tumours were hyperintense and 41% isointense adenomas, wherein hyperintense were more invasive (according to Knosp-score) than isointense adenomas. A higher proportion of hyperintense somatotropinomas presented extrasellar-growth, suprasellar-growth and invasion of the cavernous sinus compared to isointense adenomas. Interestingly, somatostatin receptor-3 and dopamine receptor-5 (DRD5) expression levels were associated with extrasellar and/or suprasellar extension. Additionally, DRD5 was also higher in hyperintense adenomas and its expression was directly correlated with Knosp-score and with tumour diameter. Hence, T2-weighted MRI on somatotropinomas represents a potential tool to refine their diagnosis and prognosis, and could support the election of preoperative treatment, when required. application/pdf eng Springer Nature https://creativecommons.org/licenses/by/4.0/ Alhambra-Expósito, M.R., Ibáñez-Costa, A., Moreno-Moreno, P. et al. Association between radiological parameters and clinical and molecular characteristics in human somatotropinomas. Sci Rep 8, 6173 (2018). https://doi.org/10.1038/s41598-018-24260-y Pituitary diseases Reverse transcription polymerase chain reaction Association between radiological parameters and clinical and molecular characteristics in human somatotropinomas info:eu-repo/semantics/article https://doi.org/10.1038/s41598-018-24260-y info:eu-repo/grantAgreement/Junta de Andalucía//CTS-1406/ES info:eu-repo/grantAgreement/Junta de Andalucía//BIO-0139/ES info:eu-repo/grantAgreement/MINECO/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/BFU2013-43282-R/ES info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+I Orientado a los Retos de la Sociedad/BFU2016-80360-R/ES info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PI16/00264/ES info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/CP15/00156/ES info:eu-repo/semantics/openAccess