A Conserved Microbial Motif ‘Traps’ Protease Activation in Host Immunity
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Author
Sabale, Mugdha
Di Pietro, Antonio
Redkar, Amey
Publisher
Cell PressDate
2019Subject
ApoplastPapain-like cysteine proteases
Substrate
Ustilago maydis
Microbial inhibitor
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Show full item recordAbstract
A recent study (Misas-Villamil et al., Nat. Commun., 2019) reveals that Pit2, an apoplastic effector of the corn smut fungus Ustilago maydis, contains an embedded motif of 14 amino acids that binds to and inhibits plant cysteine proteases, thereby modulating host immunity. Intriguingly, the inhibitory motif acts by mimicking the protease substrate and is conserved across microbial kingdoms.