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Targeting Iron Acquisition Blocks Infection with the Fungal Pathogens Aspergillus fumigatus and Fusarium oxysporum
(Public Library of Science, 2013)
Filamentous fungi are an important cause of pulmonary and systemic morbidity and mortality, and also cause corneal
blindness and visual impairment worldwide. Utilizing in vitro neutrophil killing assays and a model of ...
Hyphal Growth of Phagocytosed Fusarium oxysporum Causes Cell Lysis and Death of Murine Macrophages
(PLOS, 2014)
Fusarium oxysporum is an important plant pathogen and an opportunistic pathogen of humans. Here we investigated phagocytosis of F. oxysporum by J774.1 murine cell line macrophages using live cell video microscopy. Macrophages ...
HapX-Mediated Iron Homeostasis Is Essential for Rhizosphere Competence and Virulence of the Soilborne Pathogen Fusarium oxysporum
(ASPB, 2012)
Soilborne fungal pathogens cause devastating yield losses and are highly persistent and difficult to control. During the infection process, these organisms must cope with limited availability of iron. Here we show that the ...
Murine Model for Fusarium oxysporum Invasive Fusariosis Reveals Organ-Specific Structures for Dissemination and Long-Term Persistence
(PLOS, 2014)
The soil-borne plant pathogen Fusarium oxysporum causes life-threatening invasive fusariosis in immunocompromised individuals. The mechanism of infection in mammalian hosts is largely unknown. In the present study we show ...
A PR-1-like Protein of Fusarium oxysporum Functions in Virulence on Mammalian Hosts
(American Society for Biochemistry and Molecular Biology Online, 2012)
The pathogenesis-related PR-1-like protein family comprises secreted proteins from the animal, plant, and fungal kingdoms whose biological function remains poorly understood. Here we have characterized a PR-1-like protein, ...
The homeodomain transcription factor Ste12: Connecting fungal MAPK signalling to plant pathogenicity
(Landes Bioscience, 2010)
A conserved mitogen-activated protein kinase (MAPK) cascade orthologous to
the mating/filamentation MAPK pathway in yeast is required for fungal pathogenicity
on plants. One of the key targets of this signalling pathway ...
How alkalinization drives fungal pathogenicity
(Public Library of Science, 2017)
pH governs most, if not all, processes of life. In fungi, ambient pH acts as a potent regulator of
growth and development [1]. Studies conducted primarily in the 2 model organisms Saccharomyces
cerevisiae and Aspergillus ...
The Secreted Peptide PIP1 Amplifies Immunity through Receptor-Like Kinase 7
(Public Library of Science, 2014)
In plants, innate immune responses are initiated by plasma membrane-located pattern recognition receptors (PRRs) upon recognition of elicitors, including exogenous pathogen-associated molecular patterns (PAMPs) and endogenous ...
A Conserved Microbial Motif ‘Traps’ Protease Activation in Host Immunity
(Cell Press, 2019)
A recent study (Misas-Villamil et al., Nat. Commun., 2019) reveals that Pit2, an apoplastic effector of the corn smut fungus Ustilago maydis, contains an embedded motif of 14 amino acids that binds to and inhibits plant ...
Plant Defensins NaD1 and NaD2 Induce Different Stress Response Pathways in Fungi
(MDPI, 2016)
Nicotiana alata defensins 1 and 2 (NaD1 and NaD2) are plant defensins from the ornamental
tobacco that have antifungal activity against a variety of fungal pathogens. Some plant defensins
interact with fungal cell wall ...