Listar DBCFI-Tesis por título
Mostrando ítems 35-54 de 101
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Factores predictivos de respuesta al tratamiento del VHC en pacientes coinfectados VIH
(Universidad de Córdoba, Servicio de Publicaciones, 2013)La infección por el virus de la hepatitis C (VHC) es un problema de salud mundial que afecta a más de 170 millones de personas [1]. De ellos, aproximadamente el 20% está coinfectado por el virus de la inmunodeficiencia ... -
Fisiopatología del ejercicio en el caballo de resistencia
(Universidad de Córdoba, Servicio de Publicaciones, 2011)This work summarizes the research conducted by a multidisciplinary research group in an attempt to understand the prolonged exercise in the horse from a pathophysiological approach. The aim is to generate useful information ... -
Functional analysis and modeling of cellular signaling circuits with transcriptomic and proteomic data
(Universidad de Córdoba, UCOPress, 2021)Biomedical research models try to leverage useful insights for the sake of human health. Such models emerge from data, and, in recent years, the advent of omics technologies has revolutionized the way molecular data is ... -
Functional role and therapeutic potential of the somatostatin and ghrelin systems and their splicing variants in prostate cancer
(Universidad de Córdoba, UCOPress, 2017)El cáncer es una de las amenazas más serias y complejas para la salud de la población mundial1. En concreto, el cáncer de próstata es el segundo tipo de tumor solido más frecuente entre los hombres, y causa 300.000 muertes ... -
Hallmarks of aging in kidney from mice submitted to genetic and nutritional intervention
(Universidad de Córdoba, UCOPress, 2020)Aging should be considered as a multifactorial phenomenon and, consequently, its study should be addressed through different experimental designs. This includes nutritional and genetic interventions. In addition, it is ... -
Identificación de biomarcadores de disfunción del tejido adiposo en condiciones de resistencia a insulina
(Universidad de Córdoba, UCOPress, 2022)El constante incremento de la prevalencia de la obesidad a nivel mundial, que está alcanzando dimensiones epidémicas, constituye un grave problema de salud pública, debido al desarrollo de comorbilidades graves asociadas ... -
Identificación de la heterogeneidad molecular asociada a la enfermedad cardiovascular, la evolución clínica y la respuesta terapéutica en patologías Autoinmunes Sistémicas
(Universidad de Córdoba, UCOPress, 2022)Las enfermedades autoinmunes son enfermedades multifactoriales, resultado de la interacción entre factores genéticos, factores ambientales y alteraciones del propio sistema inmune. Entre ellas, el lupus eritematoso sistémico ... -
Identificación de marcadores predictivos en cáncer y enfermedad metabólica relacionados con la ruta de respuesta a hipoxia
(Universidad de Córdoba, UCOPress, 2018)La búsqueda de nuevos marcadores predictivos en enfermedades de alta prevalencia como el cáncer o el síndrome metabólico sigue siendo a día de hoy uno de los pilares básicos en la investigación biomédica traslacional. ... -
Identificación de nuevos marcadores del tejido adiposo en relación a obesidad y resistencia a insulina
(Universidad de Córdoba, UCOPress, 2015)INTRODUCTION The adipose tissue (AT) has been long considered to play a passive role as a fat storage depot. However, recent discoveries have significantly modified the classical view of adipose tissue as an inert energy ... -
Identification of immunosenescence markers in models of cardiovascular disease, infection, and inflammatory-based diseases
(Universidad de Córdoba, UCOPress, 2024)The immune system, a complex defense system, safeguards the body from various threats. Immunosenescence, an age-related deterioration of the immune system, is characterized by the accumulation of memory T cells and the ... -
Identification of new kinase substrates involved in the DNA Damage Response pathway and its implication in carcinogenesis
(Universidad de Córdoba, UCOPress, 2017)One of the most relevant altered pathways in cancer is the DNA Damage Response (DDR), a well-coordinated network of signalling cascades that cells have developed during evolution in order to maintain genomic integrity. ... -
Identification of novel biomarkers and therapeutic targets in the pathological interaction between the dysregulation of the endocrinemetabolic system and prostate cancer
(Universidad de Córdoba, UCOPress, 2022)Obesity (OB) is a metabolic chronic disease with a growing incidence and elevated morbidities and mortality [1, 2]. OB is also associated with elevated economic costs for the health systems representing a worldwide public ... -
Identification of novel cellular and/or molecular markers involved in the pharmacological response and contributions of splicing mechanisms in pituitary tumors
(Universidad de Córdoba, UCOPress, 2019) -
Identification of novel clinical and molecular factors for the diagnosis and aggressiveness of prostate cancer
(Universidad de Córdoba, UCOPress, 2019)Prostate cancer (PCa) is the most common solid neoplasm in men in developed countries. Unfortunately, the extraordinary heterogeneity and complexity of PCa, together with its phenotypic/clinical variability, strongly ... -
Identification of novel endocrine-metabolic and splicing machinery factors with diagnostic, prognostic and/or therapeutic potential in prostate cancer
(Universidad de Córdoba, UCOPress, 2020)Prostate cancer (PCa) is the tumor pathology with the highest incidence among men in developed countries and represents one of the main causes of cancer-related death in this group. Despite the advances achieved during the ... -
Identification of Novel Markers and Molecular Mechanisms with Diagnostic, Prognostic, and Therapeutic Potential in Brain Tumors
(Universidad de Córdoba, UCOPress, 2022)Primary brain tumors represent a highly variable and heterogeneous group of neoplasms (~150 different types) that includes non-malignant and malignant tumors. The most frequent malignant brain tumors are gliomas (representing ... -
Identification of novel molecular markers and contribution of splicing mechanisms in endocrine-related tumoral pathologies
(Universidad de Córdoba, UCOPress, 2020)Cancer represents one of the main challenges for the human being, in that it encompasses some of the most severe and health-threatening pathologies worldwide. Although great efforts are being implemented and significant ... -
Identification of novel molecular markers in pituitary tumors: contribution to pathogenesis and therapeutic potential
(Universidad de Córdoba, UCOPress, 2015)Los adenomas hipofisarios se han considerado comúnmente como una patología tumoral infrecuente debido, posiblemente, a una subestimación en su diagnóstico y consecuentemente, baja incidencia; sin embargo, resultados de ... -
Impacto de la capacidad de fijación C1Q de los anticuerpos preformados específicos de donante sobre la evolución del aloinjerto renal
(Universidad de Córdoba, UCOPress, 2018)Introducción. La consolidación del ensayo single antigen beads (SABpanIgG) como método para la detección de anticuerpos frente a antígenos leucocitarios humanos (HLA), sin duda ha mejorado las expectativas de éxito en ... -
Implication of the alternative splicing process in the development of hepatocelular carcinoma
(Universidad de Córdoba, UCOPress, 2021)Liver cancer represents a complex and heterogeneous pathology that encompasses several types of malignant tumors with unfavorable characteristics and prognosis, including hepatocellular carcinoma or hepatocarcinoma (HCC). ...