Nanostructured TiO2 Carbon Paste Based Sensor for Determination of Methyldopa
Autor
Ferreira Garcia, Luane
Peixoto da Cunha, Carlos Eduardo
Kussmaul Gonçalves Moreno, Emily
Vieira Thomaz, Douglas
Sanz Lobón, Germán
Luque, Rafael
Somerset, Vernon
Souza Gil, Eric de
Editor
MDPIFecha
2018Materia
Pencil graphiteMetal oxide nanostructures
Low cost
Phenolic drug
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Methyldopa is a catecholamine widely used in the treatment of mild to moderate
hypertension whose determination in pharmaceutical formulae is of upmost importance for dose
precision. Henceforth, a low-cost carbon paste electrode (CPE) consisting of graphite powder obtained
from a crushed pencil stick was herein modified with nanostructured TiO2 (TiO2@CPE) aiming for
the detection of methyldopa in pharmaceutical samples. The TiO2-modified graphite powder was
characterized by scanning electron microscopy and X-ray diffraction, which demonstrated the oxide
nanostructured morphology. Results evidenced that sensitivity was nonetheless increased due to
electro-catalytic effects promoted by metal modification, and linear response obtained by differential
pulse voltammetry for the determination of methyldopa (pH = 5.0) was between 10–180 mol/L
(Limit of Detection = 1 mol/L) with the TiO2@CPE sensor. Furthermore, the constructed sensor was
successfully applied in the detection of methyldopa in pharmaceutical formulations and excipients
promoted no interference, that indicates that the sensor herein developed is a cheap, reliable, and
useful strategy to detect methyldopa in pharmaceutical samples, and may also be applicable in
determinations of similar compounds.