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Nanostructured TiO2 Carbon Paste Based Sensor for Determination of Methyldopa
dc.contributor.author | Ferreira Garcia, Luane | |
dc.contributor.author | Peixoto da Cunha, Carlos Eduardo | |
dc.contributor.author | Kussmaul Gonçalves Moreno, Emily | |
dc.contributor.author | Vieira Thomaz, Douglas | |
dc.contributor.author | Sanz Lobón, Germán | |
dc.contributor.author | Luque, Rafael | |
dc.contributor.author | Somerset, Vernon | |
dc.contributor.author | Souza Gil, Eric de | |
dc.date.accessioned | 2018-10-31T12:14:27Z | |
dc.date.available | 2018-10-31T12:14:27Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | http://hdl.handle.net/10396/17372 | |
dc.description.abstract | Methyldopa is a catecholamine widely used in the treatment of mild to moderate hypertension whose determination in pharmaceutical formulae is of upmost importance for dose precision. Henceforth, a low-cost carbon paste electrode (CPE) consisting of graphite powder obtained from a crushed pencil stick was herein modified with nanostructured TiO2 (TiO2@CPE) aiming for the detection of methyldopa in pharmaceutical samples. The TiO2-modified graphite powder was characterized by scanning electron microscopy and X-ray diffraction, which demonstrated the oxide nanostructured morphology. Results evidenced that sensitivity was nonetheless increased due to electro-catalytic effects promoted by metal modification, and linear response obtained by differential pulse voltammetry for the determination of methyldopa (pH = 5.0) was between 10–180 mol/L (Limit of Detection = 1 mol/L) with the TiO2@CPE sensor. Furthermore, the constructed sensor was successfully applied in the detection of methyldopa in pharmaceutical formulations and excipients promoted no interference, that indicates that the sensor herein developed is a cheap, reliable, and useful strategy to detect methyldopa in pharmaceutical samples, and may also be applicable in determinations of similar compounds. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.source | Pharmaceuticals 11, 99 (2018) | es_ES |
dc.subject | Pencil graphite | es_ES |
dc.subject | Metal oxide nanostructures | es_ES |
dc.subject | Low cost | es_ES |
dc.subject | Phenolic drug | es_ES |
dc.title | Nanostructured TiO2 Carbon Paste Based Sensor for Determination of Methyldopa | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.3390/ph11040099 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |