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Immunomodulatory and Inhibitory Effect of Immulina®, and Immunloges® in the Ig-E Mediated Activation of RBL-2H3 Cells. A New Role in Allergic Inflammatory Responses
dc.contributor.author | Appel, Kurt | |
dc.contributor.author | Muñoz, Eduardo | |
dc.contributor.author | Navarrete, Carmen | |
dc.contributor.author | Cruz Teno, Cristina | |
dc.contributor.author | Biller, Andreas | |
dc.contributor.author | Thiemann, Eva | |
dc.date.accessioned | 2018-10-31T12:24:45Z | |
dc.date.available | 2018-10-31T12:24:45Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | http://hdl.handle.net/10396/17374 | |
dc.description.abstract | Immulina®, a high-molecular-weight polysaccharide extract from the cyanobacterium Arthrospira platensis (Spirulina) is a potent activator of innate immune cells. On the other hand, it is well documented that Spirulina exerts anti-inflammatory effects and showed promising effects with respect to the relief of allergic rhinitis symptoms. Taking into account these findings, we decided to elucidate whether Immulina®, and immunLoges® (a commercial available multicomponent nutraceutical with Immulina® as a main ingredient) beyond immune-enhancing effects, might also exert inhibitory effects in the induced allergic inflammatory response and on histamine release from RBL-2H3 mast cells. Our findings show that Immulina® and immunLoges® inhibited the IgE-antigen complex-induced production of TNF- , IL-4, leukotrienes and histamine. The compound 48/80 stimulated histamine release in RBL-2H3 cells was also inhibited. Taken together, our results showed that Immulina® and immunLoges® exhibit anti-inflammatory properties and inhibited the release of histamine from mast cells. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.source | Plants 7, 13 (2018) | es_ES |
dc.subject | Allergy | es_ES |
dc.subject | Inflammation | es_ES |
dc.subject | Mast cells | es_ES |
dc.subject | Immulina® | es_ES |
dc.subject | ImmunLoges | es_ES |
dc.title | Immunomodulatory and Inhibitory Effect of Immulina®, and Immunloges® in the Ig-E Mediated Activation of RBL-2H3 Cells. A New Role in Allergic Inflammatory Responses | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.3390/plants7010013 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |