Browsing DAAPC-Artículos, capítulos... by Author "32e6a0b9-5f13-4692-a9be-c28224fccd66"
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A Partially Protective Vaccine for Fasciola hepatica Induced Degeneration of Adult Flukes Associated to a Severe Granulomatous Reaction in Sheep
Molina Hernández, Verónica; Ruiz-Campillo, María Teresa; Martínez-Moreno, Francisco Javier; Buffoni Perazzo, Leandro; Martínez-Moreno, Álvaro; Zafra Leva, Rafael; Escamilla, Alejandro; Pérez Caballero, Raúl; Pérez Arévalo, José (MDPI, 2021)Fasciolosis is an important economic disease of livestock. There is a global interest in the development of protective vaccines since current anthelmintic therapy is no longer sustainable. A better knowledge of the ... -
Apoptosis of peritoneal leucocytes during early stages of Fasciola hepatica infections in sheep
Escamilla, Alejandro; Pérez Caballero, Raúl; Zafra Leva, Rafael; Bautista, M.J.; Pacheco, I.L.; Ruiz, M.Teresa; Martínez Cruz, Setefilla; Martínez-Moreno, Álvaro; Molina Hernández, Verónica; Pérez, José (Elsevier, 2017)Several immunomodulatory properties have been described in Fasciola hepatica infections. Apoptosis has been shown to be an effective mechanism to avoid the immune response in helminth infections. The aim of the present ... -
Comparative dynamics of peritoneal cell immunophenotypes in sheep during the early and late stages of the infection with Fasciola hepatica by flow cytometric analysis
Pérez Caballero, Raúl; Martínez-Moreno, Francisco Javier; Zafra Leva, Rafael; Molina-Hernández, Verónica; Pacheco, I.L.; Ruiz-Campillo, María Teresa; Escamilla, Alejandro; Pérez, José; Martínez Moreno, Álvaro; Buffoni Perazzo, Leandro (Springer, 2018)Background: The peritoneal cell populations (PCP) are thought to play a crucial role during the early immune response in Fasciola hepatica infection while newly excysted juveniles (NEJ) are migrating in the peritoneal ... -
Expression of free radicals by peritoneal cells of sheep during the early stages of Fasciola hepatica infection
Pérez Caballero, Raúl; Buffoni Perazzo, Leandro; Martínez-Moreno, Francisco Javier; Zafra Leva, Rafael; Molina-Hernández, Verónica; Pérez, José; Martínez Moreno, Álvaro (Springer, 2018)Background: The majority of vaccination studies against infection with F. hepatica in a natural host have been conducted at the late stage of the infection when the host's immune response is already immunomodulated by the ... -
Fasciola hepatica induces Foxp3 T cell, proinflammatory and regulatory cytokine overexpression in liver from infected sheep during early stages of infection
Pacheco, Isabel; Abril, Nieves; Zafra Leva, Rafael; Molina-Hernández, Verónica; Morales‑Prieto2, Noelia; Bautista, M.J.; Ruiz-Campillo, María Teresa; Pérez Caballero, Raúl; Martínez Moreno, Álvaro; Pérez, José (Springer, 2018)The expression of T regulatory cells (Foxp3), regulatory (interleukin [IL]-10 and transforming growth factor beta [TGF-β]) and proinflammatory (tumor necrosis factor alpha [TNF-α] and interleukin [IL]-1β) cytokines was ... -
Identification of protective peptides of Fasciola hepatica-derived cathepsin L1 (FhCL1) in vaccinated sheep by a linear B-cell epitope mapping approach
Buffoni Perazzo, Leandro; Garza-Cuartero, Laura; Pérez Caballero, Raúl; Zafra Leva, Rafael; Martínez-Moreno, Francisco Javier; Molina-Hernández, Verónica; Pérez, José; Martínez Moreno, Álvaro; Mulcahy, Grace (Springer, 2020)Background: Fasciolosis is one of the most important parasitic diseases of livestock. The need for better control strategies gave rise to the identification of various vaccine candidates. The recombinant form of a member ... -
Identification of reference genes for real-time PCR cytokine gene expression studies in sheep experimentally infected with Fasciola hepatica
Pacheco, I.L.; Abril, Nieves; Zafra Leva, Rafael; Morales-Prieto, N.; Molina Hernández, Verónica; Ruiz, M.T.; Pérez Caballero, Raúl; Martínez-Moreno, Álvaro; Pérez, José (Nature.com, 2019)The aim of this study was to validate reference genes for gene normalisation using qRT-PCR in hepatic lymph nodes (HLN) and livers from sheep infected with Fasciola hepatica during early and late stages of infection. To ... -
Serosurveillance of Trichinella sp. in wild boar and Iberian domestic suids in Mediterranean ecosystems of southwestern Spain
Buffoni Perazzo, Leandro; Cano Terriza, David; Jiménez-Martín, Débora; Jiménez-Ruiz, Saúl; Martínez Moreno, Álvaro; Martínez-Moreno, Francisco Javier; Zafra Leva, Rafael; Pérez Caballero, Raúl; Risalde, M.A.; Gómez-Guillamón, Félix; García-Bocanegra, Ignacio (Wiley, 2023)Aims: A cross-sectional study was carried out to assess the seroprevalence and risk factors associated with Trichinella spp. exposure in wild boar and Iberian domestic pigs from Mediterranean ecosystems of southwestern ... -
Vaccines against helminth parasites of livestock of economic and/or public health significance (PARAVAC)
Zafra Leva, Rafael; Pérez, José; Escamilla, Alejandro; Buffoni Perazzo, Leandro; Pérez Caballero, Raúl; Redacción TR-UCO (Oficina de Transferencia de Resultados de la Investigación, 2013)El proyecto PARAVAC está financiado por el VII Programa Marco con una aportación de la Comisión Europea de unos 9 millones de euros. El principal objetivo de este proyecto es el desarrollo y comercialización de vacunas ...