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Immune Checkpoint Inhibitors for the Treatment of Bladder Cancer
(MDPI, 2021)
A number of immune checkpoint inhibitors (ICIs) have been approved as first-line therapy in case of cisplatin-ineligible patients or as second-line therapy for patients with metastatic urothelial carcinoma (mUC) of the ...
Increased 1,25(OH)2-Vitamin D Concentrations after Energy Restriction Are Associated with Changes in Skeletal Muscle Phenotype
(MDPI, 2021)
The influence of energy restriction (ER) on muscle is controversial, and the mechanisms are not well understood. To study the effect of ER on skeletal muscle phenotype and the influence of vitamin D, rats (n = 34) were fed ...
Androgen Receptor Signaling Pathway in Prostate Cancer: From Genetics to Clinical Applications
(MDPI, 2020)
Around 80–90% of prostate cancer (PCa) cases are dependent on androgens at initial diagnosis; hence, androgen ablation therapy directed toward a reduction in serum androgens and the inhibition of androgen receptor (AR) is ...
New Frontiers in Prostate Cancer Treatment: Are We Ready for Drug Combinations with Novel Agents?
(MDPI, 2020)
Medical treatment for metastatic castration-resistant prostate cancer (mCRPC) patients has progressively been evolving from a nonspecific clinical approach to genomics-oriented therapies. The scientific community is in ...
A Multiplex Test Assessing MiR663ame and VIMme in Urine Accurately Discriminates Bladder Cancer from Inflammatory Conditions
(MDPI, 2020)
Bladder cancer (BlCa) is a common malignancy with significant morbidity and mortality. Current diagnostic methods are invasive and costly, showing the need for newer biomarkers. Although several epigenetic-based biomarkers ...
Maxillary Incisors of the Horse before and at the Beginning of the Teeth Shedding: Radiographic and CT Study
(MDPI, 2020)
To gain insight into the radiographic appearance of maxillary deciduous incisors and dental germs of maxillary permanent incisors in the period prior to teeth shedding, radiographs and computed tomography (CT) of 25 horse ...
Surface Electromyography of the Longissimus and Gluteus Medius Muscles in Greyhounds Walking and Trotting on Ground Flat, Up, and Downhill
(MDPI, 2020)
In the field of canine rehabilitation, knowledge of muscle function in the therapeutic exercises prescribed is needed by physical therapists and veterinary surgeons. To gain insight into the function of longissimus dorsi ...
Current Strategies and Novel Therapeutic Approaches for Metastatic Urothelial Carcinoma
(MDPI, 2020)
Urothelial carcinoma (UC) is a frequent cause of cancer-related deaths worldwide. Metastatic UC has been historically associated with poor prognosis, with a median overall survival of approximately 15 months and a 5-year ...
Update on Circulating Tumor Cells in Genitourinary Tumors with Focus on Prostate Cancer
(MDPI, 2020)
Current developments in the treatment of genitourinary tumors underline the unmet clinical need for biomarkers to improve decision-making in a challenging clinical setting. The detection of circulating tumor cells (CTCs) ...
Androgen and Estrogen Receptor Expression in Different Types of Perianal Gland Tumors in Male Dogs
(MDPI, 2021)
Perianal gland tumors are modified sebaceous glands present in the skin of the perianal region in the dog. Hormonal stimulation may induce hyperplasia of the perianal glands or their neoplastic progression. The presence ...