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Progesterone receptor isoform A may regulate the effects of neoadjuvant aglepristone in canine mammary carcinoma
(BioMed Central, 2014)
Background: Progesterone receptors play a key role in the development of canine mammary tumours, and recent
research has focussed on their possible value as therapeutic targets using antiprogestins. Cloning and sequencing
of ...
Progesterone Receptor Isoform Analysis by Quantitative Real-Time Polymerase Chain Reaction in Formalin-Fixed, Paraffin-Embedded Canine Mammary Dysplasias and Tumors
(Sage, 2014)
Cloning and sequencing of the progesterone receptor gene in dogs have revealed 2 isoforms, A and B, transcribed from a single gene. Distribution of isoforms A and B in canine mammary lesions has hitherto been investigated ...
Aglepristone decreases proliferation in progesterone receptor-positive canine mammary carcinomas
(Wiley, 2011)
Progesterone receptor (PR) antagonist aglepristone (RU534) has been used successfully for pregnancy termination and therapy of pyometra, vaginal tumors, and mammary hyperplasia in bitches and queens. All of these conditions ...
Expression of the Short Form of RON/STK in Feline Mammary Carcinoma
(Sage, 2019)
RON is a tyrosine kinase receptor activated by the macrophage-stimulating protein (MSP) ligand that is overexpressed in human breast cancer. In humans, RON protein can be present in different isoforms, and the most studied ...
Use of CD10 as a marker of canine mammary myoepithelial cells
(Elsevier, 2013)
CD10 is an important cell marker in the diagnosis of acute lymphoblastic leukaemia and of breast myoepithelial (ME) cells in humans. The objective of this study was to assess the value of CD10 as a marker of canine ME cells ...
Myoepithelial cells in canine mammary tumours
(Elsevier, 2016)
Mammary tumours are the most common neoplasms of female dogs. Compared to mammary tumours of humans and cats, myoepithelial (ME) cell involvement is common in canine mammary tumours (CMT) of any subtype. Since ME cell ...
Sex Steroid Hormones and Tumors in Domestic Animals
(Intech, 2013)
Sex steroid hormones play a role in the development and control of animal tumours, particularly
in those arising in their target organs. Due to their incidence and prevalence, mammary
tumours of female dogs and cats are ...
Myoepithelial cell layer integrity in canine mammary carcinoma
(Elsevier, 2011)
The aim of this study was to determine whether the myoepithelial (ME) cell marker calponin could be used to analyze the integrity of the ME cell layer as a means of identifying canine mammary carcinoma in situ. Tissue from ...