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Androgen Receptor Signaling Pathway in Prostate Cancer: From Genetics to Clinical Applications
(MDPI, 2020)
Around 80–90% of prostate cancer (PCa) cases are dependent on androgens at initial diagnosis; hence, androgen ablation therapy directed toward a reduction in serum androgens and the inhibition of androgen receptor (AR) is ...
New Frontiers in Prostate Cancer Treatment: Are We Ready for Drug Combinations with Novel Agents?
(MDPI, 2020)
Medical treatment for metastatic castration-resistant prostate cancer (mCRPC) patients has progressively been evolving from a nonspecific clinical approach to genomics-oriented therapies. The scientific community is in ...
A Multiplex Test Assessing MiR663ame and VIMme in Urine Accurately Discriminates Bladder Cancer from Inflammatory Conditions
(MDPI, 2020)
Bladder cancer (BlCa) is a common malignancy with significant morbidity and mortality. Current diagnostic methods are invasive and costly, showing the need for newer biomarkers. Although several epigenetic-based biomarkers ...
Maxillary Incisors of the Horse before and at the Beginning of the Teeth Shedding: Radiographic and CT Study
(MDPI, 2020)
To gain insight into the radiographic appearance of maxillary deciduous incisors and dental germs of maxillary permanent incisors in the period prior to teeth shedding, radiographs and computed tomography (CT) of 25 horse ...
Surface Electromyography of the Longissimus and Gluteus Medius Muscles in Greyhounds Walking and Trotting on Ground Flat, Up, and Downhill
(MDPI, 2020)
In the field of canine rehabilitation, knowledge of muscle function in the therapeutic exercises prescribed is needed by physical therapists and veterinary surgeons. To gain insight into the function of longissimus dorsi ...
Current Strategies and Novel Therapeutic Approaches for Metastatic Urothelial Carcinoma
(MDPI, 2020)
Urothelial carcinoma (UC) is a frequent cause of cancer-related deaths worldwide. Metastatic UC has been historically associated with poor prognosis, with a median overall survival of approximately 15 months and a 5-year ...
Update on Circulating Tumor Cells in Genitourinary Tumors with Focus on Prostate Cancer
(MDPI, 2020)
Current developments in the treatment of genitourinary tumors underline the unmet clinical need for biomarkers to improve decision-making in a challenging clinical setting. The detection of circulating tumor cells (CTCs) ...
Characterization of dendritic cells and follicular dendritic cells in the hepatic lymph nodes and liver of sheep experimentally infected with Fasciola hepatica
(Springer, 2020)
Fasciola hepatica has been shown to have a high capacity for immunomodulation of the host response, making the development of protective vaccines extremely difficult. One of these immunomodulation mechanisms is the impairment ...
Identification of protective peptides of Fasciola hepatica-derived cathepsin L1 (FhCL1) in vaccinated sheep by a linear B-cell epitope mapping approach
(Springer, 2020)
Background: Fasciolosis is one of the most important parasitic diseases of livestock. The need for better control strategies
gave rise to the identification of various vaccine candidates. The recombinant form of a member ...