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A Partially Protective Vaccine for Fasciola hepatica Induced Degeneration of Adult Flukes Associated to a Severe Granulomatous Reaction in Sheep
(MDPI, 2021)
Fasciolosis is an important economic disease of livestock. There is a global interest in the development of protective vaccines since current anthelmintic therapy is no longer sustainable. A better knowledge of the ...
Fasciola hepatica primoinfections and reinfections in sheep drive distinct Th1/Th2/Treg immune responses in liver and hepatic lymph node at early and late stages
(Springer, 2023)
The expression of proinflammatory (IL-1β, IFN-γ, TNF-α) and regulatory (IL-10, TGF-β, IL-4) cytokines, as well as the
transcription factor FoxP3, was quantified in the liver and hepatic lymph node (HLN) of sheep primoinfected ...
Characterization of dendritic cells and follicular dendritic cells in the hepatic lymph nodes and liver of sheep experimentally infected with Fasciola hepatica
(Springer, 2020)
Fasciola hepatica has been shown to have a high capacity for immunomodulation of the host response, making the development of protective vaccines extremely difficult. One of these immunomodulation mechanisms is the impairment ...
Identification of protective peptides of Fasciola hepatica-derived cathepsin L1 (FhCL1) in vaccinated sheep by a linear B-cell epitope mapping approach
(Springer, 2020)
Background: Fasciolosis is one of the most important parasitic diseases of livestock. The need for better control strategies
gave rise to the identification of various vaccine candidates. The recombinant form of a member ...
Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine development
(Frontiers, 2023)
Fasciola hepatica has a worldwide distribution causing important economic losses in animal production industry. Human fasciolosis is considered an emerging zoonosis in areas of Andean America, Asia, and Africa. The control ...