Artículos, capítulos, libros...UCO

 

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  • PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing 

    López Cánovas, Juan Luis; Hermán Sánchez, Natalia; Río Moreno, Mercedes del; Fuentes-Fayos, Antonio C.; Lara López, Araceli; Sánchez-Frías, Marina; Amado-Torres, Víctor; Ciria, Rubén; Briceño Delgado, Francisco Javier; Mata, Manuel de la; Castaño, Justo P.; Rodríguez-Perálvarez, Manuel; Luque, Raúl M.; Gahete Ortiz, Manuel D. (Springer Nature, 2023)
    Hepatocellular carcinoma (HCC) pathogenesis is associated with alterations in splicing machinery components (spliceosome and splicing factors) and aberrant expression of oncogenic splice variants. We aimed to analyze the ...

  • Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing 

    López Cánovas, Juan Luis; Hermán Sánchez, Natalia; Moreno Montilla, M. Trinidad; Río Moreno, Mercedes del; Alors-Pérez, Emilia; Sánchez-Frías, Marina; Amado-Torres, Víctor; Ciria, Rubén; Briceño Delgado, Francisco Javier; Mata, Manuel de la; Castaño, Justo P.; Rodríguez-Perálvarez, Manuel; Luque, Raúl M.; Gahete Ortiz, Manuel D. (Wiley, 2022)
    Introduction: Altered splicing landscape is an emerging cancer hallmark; however, the dysregulation and implication of the cellularmachinery controlling this process (spliceosome components and splicing factors) in ...

  • Changes in Splicing Machinery Components Influence, Precede, and Early Predict the Development of Type 2 Diabetes: From the CORDIOPREV Study 

    Gahete Ortiz, Manuel D.; Río Moreno, Mercedes del; Carpio Camargo, Antonio José; Alcalá Díaz, Juan Francisco; Alors-Pérez, Emilia; Delgado-Lista, Javier; Reyes Pupo, Oscar Gabriel; Ventura, Sebastián; Pérez Martínez, Pablo; Castaño, Justo P.; López Miranda, José; Luque, Raúl M. (Elsevier, 2018)
    Background: Type-2 diabetes mellitus (T2DM) is a major health problem with increasing incidence, which severely impacts cardiovascular disease. Because T2DM is associated with altered gene expression and aberrant splicing, ...

  • Graph-Based Feature Selection Approach for Molecular Activity Prediction 

    Cerruela García, Gonzalo; Cuevas-Muñoz, José Manuel; García Pedrajas, Nicolás (American Chemical Society, 2022)
    In the construction of QSAR models for the prediction of molecular activity, feature selection is a common task aimed at improving the results and understanding of the problem. The selection of features allows elimination ...

  • A Review of the Use of Hydrogen in Compression Ignition Engines with Dual-Fuel Technology and Techniques for Reducing NOx Emissions 

    Rueda-Vázquez, Juan Manuel; Serrano González, Javier; Pinzi, Sara; Jiménez Espadafor, Francisco José; Dorado, M.P. (MDPI, 2024)
    The use of compression ignition engines (CIEs) is associated with increased greenhouse gas emissions. It is therefore necessary to research sustainable solutions and reduce the negative environmental impact of these engines. ...

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