Vitamin d deficiency with high parathyroid hormone levels is related to late onset SEPSIS among preterm infants
Author
Tofe‑Valera, I.
Pérez Navero, Juan Luis
Caballero‑Villarras, J.
Cañete, M. D.
Villa Jiménez, Rosalía
Torre‑Aguilar, M. J. de la
Publisher
BMCDate
2023Subject
25(OH) D levelsVitamin D defciency
Preterm infants
Low birth weight
Sepsis
Parathyroid hormone
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Summary Preterm infants (PTs) are at greater risk for vitamin D defciency, which relates to the possibility of a higher incidence of comorbidities. Our goal was twofold, 1) to monitor vitamin D, calcium, phosphorus, parathyroid hormone (PTH), matrix metalloproteinase-8 (MMP-8) serum levels at three-time points during hospitalization, and 2) to assess the association between 25-hydroxyvitamin D (25OHD) levels and outcomes in PTs. Methods We carried out a follow-up on 50 Caucasian PTs≤32weeks of gestational age (GA) and/or≤1500g birth weight at 28days and at 4months. PTs were divided into two subgroups for tests of association with clinical outcomes based on vitamin D defcient infants 25(OH) D cord blood levels: ≤ 20ng/ml). At an initial stage, 25(OH) D levels were determined in maternal/preterm blood samples and were compared to full term delivery infants. Results There were no diferences in 25(OH) D serum levels at birth when comparing PTs to term infants, or regard ing maternal levels. A strong positive correlation was detected between maternal and neonatal 25(OH) D serum levels among PTs and term infants (r: 0.466; p60pg/mL; group 2: vitamin D>20 and PTH