Diabetes Remission Is Modulated by Branched Chain Amino Acids According to the Diet Consumed: From the CORDIOPREV Study
Autor
Cardelo, Magdalena P.
Alcalá Díaz, Juan Francisco
Gutiérrez Mariscal, Francisco Miguel
López Moreno, Javier
Villasanta-González, Alejandro
Arenas de Larriva, Antonio P.
Cruz Ares, Silvia de la
Delgado-Lista, Javier
Rodríguez-Cantalejo, Fernando
Luque, Raúl M.
Ordovás, José María
Pérez Martínez, Pablo
Camargo García, A.
López Miranda, José
Editor
WileyFecha
2021Materia
Branched chain amino acidsCORDIOPREV study
Mediterranean diet
Type 2 diabetes remission
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Scope:
Branched Chain Amino Acids (BCAA) plasma levels may be differentially associated with type 2 diabetes mellitus (T2DM) remission through the consumption of the Mediterranean diet (Med) and a low-fat (LF) diet.
Methods:
One hundred eighty-three newly diagnosed T2DM patients within the CORDIOPREV study are randomized to consume the Med or a LF diet. BCAA plasma levels (isoleucine, leucine, and valine) are measured at fasting and after 120 min of an oral glucose tolerance test (OGTT) at the baseline of the study and after 5 years of the dietary intervention.
Results:
Isoleucine, leucine, and valine plasma levels after 120 min of an OGTT in the Med diet (N = 80) are associated by COX analysis with T2DM remission: HR per SD (95% CI): 0.53 (0.37–0.77), 0.75 (0.52–1.08), and 0.61 (0.45–0.82), respectively; no association is found in patients who consumed a LF diet (N = 103). BCAA plasma levels combined in a score show a HR of 3.33 (1.55–7.19) of T2DM remission for patients with a high score values in the Med diet, while in those with a LF diet, no association is found.
Conclusión:
The study suggests that BCAA measurements potentially be used as a tool to select the most suitable diet to induce T2DM remission by nutritional strategies.