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Melanotrope Secretory Cycle is Regulated by Physiological Inputs via the Hypothalamus
(2017-03-17)
Previously, it has been shown that background color conditions regulate the
overall activity of the frog intermediate lobe by varying the proportions of the
two subtypes of melanotropes existing in the gland, the highly ...
Role of Endogenous Cortistatin in the Regulation of Ghrelin System Expression at Pancreatic Level under Normal and Obese Conditions
(Public Library Of Science (PLOS), 2013)
Ghrelin-system components [native ghrelin, In1-ghrelin, Ghrelin-O-acyltransferase enzyme (GOAT) and receptors (GHS-Rs)]
are expressed in a wide variety of tissues, including the pancreas, where they exert different ...
Nutritional, hormonal, and depot-dependent regulation of the expression of the small GTPase Rab18 in rodent adipose tissue
(Society for Endocrinology, 2013)
There is increasing evidence that proteins associated with lipid droplets (LDs) play a key role in the coordination of lipid storage and mobilization in adipocytes. The small GTPase, RAB18, has been recently identified as ...
Peptides derived from the extracellular domain of the somatostatin receptor splicing variant 1 SST5TMD4 increase malignancy in multiple cancer cell types
(Elsevier, 2019)
Extracellular fragments derived from plasma membrane receptors can play relevant roles in the development/progression of tumor pathologies, thereby offering novel diagnostic or therapeutic opportunities. The truncated ...
Changes in Splicing Machinery Components Influence, Precede, and Early Predict the Development of Type 2 Diabetes: From the CORDIOPREV Study
(Elsevier, 2018)
Background: Type-2 diabetes mellitus (T2DM) is a major health problem with increasing incidence, which severely impacts cardiovascular disease. Because T2DM is associated with altered gene expression and aberrant splicing, ...