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A genome-wide association study of mare fertility in the Pura Raza Español horse
(Elsevier, 2022)
Despite the economic importance of fertility for the horse industry, few efforts have been made to achieve a better understanding of the genetic mechanisms underlying its control. This is probably due to the difficulty of ...
MicroRNAs and GRK2 as modulators of Kiss1/GPR54 system: Physiopathological role in pubertal alterations and obesity induced hypogonadism
(Universidad de Córdoba, UCOPress, 2023)
The reproductive function is governed by the so-called hypothalamic-pituitary-gonadal (HPG) axis, where an intricated network of central, peripheral and external factors determine hormonal balance and proper functioning ...
Synergistic antibacterial effects of amoxicillin and gold nanoparticles: a therapeutic option to combat antibiotic resistance
(MDPI, 2023)
Compacted Au@16-mph-16/DNA-AMOX (NSi) nanosystems were prepared from amoxicillin (AMOX) and precursor Au@16-mph-16 gold nanoparticles (Ni) using a Deoxyribonucleic acid (DNA) biopolymer as a glue. The synthesized nanocarrier ...
Novel regulatory mechanisms of Kiss1 neurons during reproductive axis development and in conditions of metabolic stress: Analysis of the roles of microRNAs and elements of the secretory pathway
(Universidad de Córdoba, UCOPress, 2023)
Reproduction is indispensable for the perpetuation of the species. Therefore, it is safeguarded by a sophisticated network of regulatory mechanisms that ultimately controls the reproductive function by modulating the ...
Matriz extracelular y fibrosis en el tejido adiposo en obesidad y resistencia a insulina
(Universidad de Córdoba, UCOPress, 2023)
La ECM del tejido adiposo es fundamental para mantener la homeostasis del tejido, así como para la formación y mantenimiento de la estructura del propio tejido (Divoux & Clement, 2011). Como en otros tejidos, la ECM del ...
LRP10, PGK1 and RPLP0: best reference genes in periprostatic adipose tissue under obesity and prostate cancer conditions
(MDPI, 2023)
Obesity (OB) is a metabolic disorder characterized by adipose tissue dysfunction that has emerged as a health problem of epidemic proportions in recent decades. OB is associated with multiple comorbidities, including some ...
Role of Toll-like receptor 4 in intravascular hemolysis-mediated injury
(Wiley, 2022)
Massive intravascular hemolysis is a common characteristic of several pathologies. It is associated with the release of large quantities of heme into the circulation, promoting injury in vulnerable organs, mainly kidney, ...
Nuevos mecanismos de control de la proteína supresora de tumores FBXW7 mediados por la quinasa DYRK2
(Universidad de Córdoba, UCOPress, 2023)
The systems responsible for protein homeostasis play a fundamental role in the development of tumors. These systems recognize and degrade incomplete, misfolded proteins or act as control mechanisms for cellular processes. ...
Rab18 dynamics in adipocytes in relation to lipogenesis, lipolysis and obesity
(PLOS, 2011)
Lipid droplets (LDs) are organelles that coordinate lipid storage and mobilization, both processes being especially important in cells specialized in managing fat, the adipocytes. Proteomic analyses of LDs have consistently ...
The ghrelin O-acyltransferase–ghrelin system reduces TNF-α-induced apoptosis and autophagy in human visceral adipocytes
(SpringerLink, 2012)
Aims/hypothesis
Proinflammatory and proapoptotic cytokines such as TNF-α are upregulated in human obesity. We evaluated the association between ghrelin isoforms (acylated and desacyl ghrelin) and TNF-α in obesity and ...