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Nuevos triterpenos hidroxamatos como activadores de HIF. Implicaciones terapéuticas
(Universidad de Córdoba, UCOPress, 2021)
El factor inducible por hipoxia (HIF) se estabiliza durante los procesos inflamatorios asociados a un gran número de patologías, produciendo cambios en la expresión génica con un profundo impacto en el microambiente tisular, ...
A plasma fatty acid profile associated to type 2 diabetes development: from the CORDIOPREV study
(Springer, 2021)
Purpose: The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. For this reason, it is essential to identify biomarkers for the early detection of T2DM risk and/or for a better prognosis of T2DM. We ...
Betulinic Acid Hydroxamate is Neuroprotective and Induces Protein Phosphatase 2A-Dependent HIF-1α Stabilization and Post-transcriptional Dephosphorylation of Prolyl Hydrolase 2
(Springer, 2021)
Huntington’s disease (HD) is a neurodegenerative disorder characterized by unwanted choreatic movements, behavioral and psychiatric disturbances, and dementia. The activation of the hypoxic response pathway through the ...
Functional analysis and modeling of cellular signaling circuits with transcriptomic and proteomic data
(Universidad de Córdoba, UCOPress, 2021)
Biomedical research models try to leverage useful insights for the sake of human health. Such models emerge from data, and, in recent years, the advent of omics technologies has revolutionized the way molecular data is ...
Identification of Novel Markers and Molecular Mechanisms with Diagnostic, Prognostic, and Therapeutic Potential in Brain Tumors
(Universidad de Córdoba, UCOPress, 2022)
Primary brain tumors represent a highly variable and heterogeneous group of neoplasms (~150 different types) that includes non-malignant and malignant tumors. The most frequent malignant brain tumors are gliomas (representing ...
Differences in Health-Related Fitness Variables between Adult Athletes and Non-Athletes with Down Syndrome: A Descriptive Study
(MDPI, 2021)
The main purpose of this study is to present objective data on the differences in anthropometrics and fitness variables between adult athletes and non-athletes with Down Syndrome (DS) members of the “Down Cordoba Association” ...
Papel de la Citocromo b5 reductasa-3 (CYB5R3) y del componente graso de la dieta en la fisiología y el envejecimiento del músculo esquelético
(Universidad de Córdoba, UCOPress, 2022)
El envejecimiento es el declive progresivo dependiente del tiempo que viene acompañado de una disminución de la fertilidad y del aumento de la susceptibilidad del organismo a amenazas tanto endógenas como externas. A lo ...
Extracellular Vesicles from Different Pneumococcal Serotypes Are Internalized by Macrophages and Induce Host Immune Responses
(MDPI, 2021)
Bacterial extracellular vesicles are membranous ultrastructures released from the cell surface. They play important roles in the interaction between the host and the bacteria. In this work, we show how extracellular vesicles ...
Determination of new DYRK2 functions in response to genotoxic stress
(Universidad de Córdoba, UCOPress, 2022)
Cancer is a complex disease enhanced by alterations in signaling pathways. In fact, DNA damage response (DDR) pathways play a key role in cancer development when they are deregulated. DDR pathways induce a cellular response ...
Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study
(MDPI, 2021)
Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing ...