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Glucokinase Regulatory Protein Genetic Variant Interacts with Omega-3 PUFA to Influence Insulin Resistance and Inflammation in Metabolic Syndrome
dc.contributor.author | García-Ríos, Antonio | |
dc.contributor.author | Mc Monagle, Jolene | |
dc.contributor.author | Gulseth, Hanne L. | |
dc.contributor.author | Ordovás, José María | |
dc.contributor.author | Shaw, Danielle I. | |
dc.contributor.author | Karlström, Brita | |
dc.contributor.author | Kiec-Wilk, Beata | |
dc.contributor.author | Blaak, Ellen E. | |
dc.contributor.author | Helal, Olfa | |
dc.contributor.author | Malczewska-Malec, Malgorzata | |
dc.contributor.author | Defoort, Catherine | |
dc.contributor.author | Risérus, Ulf | |
dc.contributor.author | Saris, Wim H.M. | |
dc.contributor.author | Lovegrove, Julie A. | |
dc.contributor.author | Drevon, Christian A. | |
dc.contributor.author | Pérez-Martínez, Pablo | |
dc.contributor.author | Delgado-Lista, Javier | |
dc.contributor.author | Roche, Helen M. | |
dc.contributor.author | López-Miranda, José | |
dc.date.accessioned | 2013-01-15T10:13:59Z | |
dc.date.available | 2013-01-15T10:13:59Z | |
dc.date.issued | 2011 | |
dc.identifier.uri | http://hdl.handle.net/10396/8639 | |
dc.description.abstract | Glucokinase Regulatory Protein (GCKR) plays a central role regulating both hepatic triglyceride and glucose metabolism. Fatty acids are key metabolic regulators, which interact with genetic factors and influence glucose metabolism and other metabolic traits. Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been of considerable interest, due to their potential to reduce metabolic syndrome (MetS) risk. Objective: To examine whether genetic variability at the GCKR gene locus was associated with the degree of insulin resistance, plasma concentrations of C-reactive protein (CRP) and n-3 PUFA in MetS subjects. Design: Homeostasis model assessment of insulin resistance (HOMA-IR), HOMA-B, plasma concentrations of C-peptide, CRP, fatty acid composition and the GCKR rs1260326-P446L polymorphism, were determined in a cross-sectional analysis of 379 subjects with MetS participating in the LIPGENE dietary cohort. Results: Among subjects with n-3 PUFA levels below the population median, carriers of the common C/C genotype had higher plasma concentrations of fasting insulin (P = 0.019), C-peptide (P = 0.004), HOMA-IR (P = 0.008) and CRP (P = 0.032) as compared with subjects carrying the minor T-allele (Leu446). In contrast, homozygous C/C carriers with n-3 PUFA levels above the median showed lower plasma concentrations of fasting insulin, peptide C, HOMA-IR and CRP, as compared with individuals with the T-allele. Conclusions: We have demonstrated a significant interaction between the GCKR rs1260326-P446L polymorphism and plasma n-3 PUFA levels modulating insulin resistance and inflammatory markers in MetS subjects. Further studies are needed to confirm this gene-diet interaction in the general population and whether targeted dietary recommendations can prevent MetS in genetically susceptible individuals | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library Of Science (PLOS) | es_ES |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/ | es_ES |
dc.source | PLoS ONE 6 (6), 1-7 (2011) | es_ES |
dc.subject | GCKR | es_ES |
dc.subject | Omega-3 | es_ES |
dc.subject | Metabolyc syndrome | es_ES |
dc.title | Glucokinase Regulatory Protein Genetic Variant Interacts with Omega-3 PUFA to Influence Insulin Resistance and Inflammation in Metabolic Syndrome | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |