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Rab18 dynamics in adipocytes in relation to lipogenesis, lipolysis and obesity
(PLOS, 2011)
Lipid droplets (LDs) are organelles that coordinate lipid storage and mobilization, both processes being especially important in cells specialized in managing fat, the adipocytes. Proteomic analyses of LDs have consistently ...
The ghrelin O-acyltransferase–ghrelin system reduces TNF-α-induced apoptosis and autophagy in human visceral adipocytes
(SpringerLink, 2012)
Aims/hypothesis
Proinflammatory and proapoptotic cytokines such as TNF-α are upregulated in human obesity. We evaluated the association between ghrelin isoforms (acylated and desacyl ghrelin) and TNF-α in obesity and ...
The stromal-vascular fraction of adipose tissue contributes to major differences between subcutaneous and visceral fat depots
(Wiley, 2010)
Adipose tissue represents a complex tissue both in terms of its cellular composition, as it includes mature adipocytes and the various cell types comprising the stromal-vascular fraction (SVF), and in relation to the ...
The l-α-Lysophosphatidylinositol/GPR55 system and its potential role in human obesity
(American Diabetes Asociation, 2012)
GPR55 is a putative cannabinoid receptor, and l-α-lysophosphatidylinositol (LPI) is its only known endogenous ligand. We investigated 1) whether GPR55 is expressed in fat and liver; 2) the correlation of both GPR55 and LPI ...
Rab18 is reduced in pituitary tumors cusing acromegaly and its overexpression reverts growth hormone hypersecretion
(Oxford Academic, 2008)
Context: Rab proteins regulate the sequential steps of intracellular membrane transport. Alterations of these GTPases and their associated proteins are emerging as the underlying cause for several human diseases involving ...
Nutritional, hormonal, and depot-dependent regulation of the expression of the small GTPase Rab18 in rodent adipose tissue
(Society for Endocrinology, 2013)
There is increasing evidence that proteins associated with lipid droplets (LDs) play a key role in the coordination of lipid storage and mobilization in adipocytes. The small GTPase, RAB18, has been recently identified as ...
Identification of novel genes involved in the plasticity of pituitary melanotropes in amphibians
(New York Academy os Sciences, 2009)
Melanotrope cells from the amphibian intermediate lobe are composed of two subpopulations that exhibit opposite secretory behavior: hypersecretory and hormone-storage hyposecretory melanotropes. Isolation of these ...
Journal article resistin regulates pituitary somatotrope cell function through the activation of multiple signaling pathways
(Endocrine Society, 2009)
The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function. Although adipose tissue is the primary source of resistin, it is also ...
Proteomic profiling of adipose tissue from Zmpste24(-/-) Mice, a model of Lipodystrophy and premature aging, reveals major changes in mitochondrial function and vimentin processing
(Science Direct, 2011)
Lipodystrophy is a major disease involving severe alterations of adipose tissue distribution and metabolism. Mutations in genes encoding the nuclear envelope protein lamin A or its processing enzyme, the metalloproteinase ...