Listar por autor "2f495340-4fe9-40c5-ae28-c58ec9766e10"
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Deficiency of Parkinson’s Related Protein DJ-1 Alters Cdk5 Signalling and Induces Neuronal Death by Aberrant Cell Cycle Re-entry
López‑Grueso, María José; Padilla, Carmen Alicia; Bárcena Ruiz, José Antonio; Requejo Aguilar, Raquel (Springer, 2022)DJ-1 is a multifunctional protein involved in Parkinson disease (PD) that can act as antioxidant, molecular chaperone, protease, glyoxalase, and transcriptional regulator. However, the exact mechanism by which DJ-1 dysfunction ... -
Loss of PRDX6 aborts proliferative and migratory signaling in hepatocarcinoma cell lines
Lagal, Daniel J.; López-Grueso, María José; Pedrajas, J.R.; Leto, Thomas L.; Bárcena, José Antonio; Requejo Aguilar, Raquel (MDPI, 2023)Peroxiredoxin 6 (PRDX6), the only mammalian 1-Cys member of the peroxiredoxin family, has peroxidase, phospholipase A2 (PLA2), and lysophosphatidylcholine (LPC) acyltransferase (LPCAT) activities. It has been associated ... -
Peroxiredoxin 6 Down-Regulation Induces Metabolic Remodeling and Cell Cycle Arrest in HepG2 Cells
López-Grueso, María José; Tarradas Valero, Rosa María; Carmona Hidalgo, Beatriz; Lagal Ruiz, Daniel; Peinado, José; McDonagh, B.; Requejo Aguilar, Raquel; Bárcena Ruiz, José Antonio; Padilla C., Alicia (MDPI, 2019)Peroxiredoxin 6 (Prdx6) is the only member of 1-Cys subfamily of peroxiredoxins in human cells. It is the only Prdx acting on phospholipid hydroperoxides possessing two additional sites with phospholipase A2 (PLA2) and ... -
Redox regulation of proteome, metabolism and signaling in hepatocarcinoma tumor cells
López-Grueso, María José (Universidad de Córdoba, UCOPress, 2019)The redoxins Thioredoxin (Trx), Glutaredoxin (Grx) and Peroxiredoxins (Prdx) play a very important role both in the maintenance of redox homeostasis and in signaling through reversible oxidation/reduction reactions in ... -
Thioredoxin Downregulation Enhances Sorafenib Effects in Hepatocarcinoma Cells
López-Grueso, María José; González, Raúl; Muntané Relat, Jordi; Bárcena Ruiz, José Antonio; Padilla, Alicia (MDPI, 2019)Sorafenib is the first-line recommended therapy for patients with advanced hepatocarcinoma (HCC) in de-differentiation stage (presenting epithelial–mesenchymal transition, EMT). We studied the role of the thioredoxin system ...