Listar por autor "a9893ae0-523f-433a-8302-eb212e6ce67c"
Mostrando ítems 1-20 de 35
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A Novel Human Ghrelin Variant (In1-Ghrelin) and Ghrelin-O-Acyltransferase Are Overexpressed in Breast Cancer: Potential Pathophysiological Relevance
Gahete Ortiz, Manuel D.; Córdoba-Chacón, José; Hergueta-Redondo, Marta; Martínez-Fuentes, Antonio J.; Kineman, Rhonda D.; Moreno-Bueno, Gema; Luque, Raúl M.; Castaño, Justo P. (Public Library Of Science (PLOS), 2011)The human ghrelin gene, which encodes the ghrelin and obestatin peptides, contains 5 exons (Ex), with Ex1-Ex4 encoding a 117 amino-acid (aa) preproprotein that is known to be processed to yield a 28-aa (ghrelin) and/or a ... -
Alternative splicing in bladder cancer: potential strategies for cancer diagnosis, prognosis, and treatment
Montero-Hidalgo, Antonio J.; Pérez-Gómez, Jesús M.; Martínez-Fuentes, Antonio J.; Gómez-Gómez, E.; Gahete Ortiz, Manuel D.; Jiménez-Vacas, J.M.; Luque, Raúl M. (Wiley, 2023)Bladder cancer is the most common malignancy of the urinary tract worldwide.The therapeutic options to tackle this disease comprise surgery, intravesical orsystemic chemotherapy, and immunotherapy. Unfortunately, a wide ... -
An altered microbiota pattern precedes Type 2 diabetes mellitus development: From the CORDIOPREV study
Vals-Delgado, Cristina; Alcalá-Diaz, Juan F.; Molina-Abril, Helena; Roncero-Ramos, Irene; Caspers, Martien P.M.; Schuren, Frank H.J.; Broek, Tim J. Van den; Luque, Raúl M.; Pérez-Martínez, Pablo; Katsiki, Niki; Delgado-Lista, Javier; Ordovas, José M.; Ommene, Ben van; Camargo García, A.; López-Miranda, José (Elsevier, 2021)Introduction. A distinctive gut microbiome have been linked to type 2 diabetes mellitus (T2DM). We aimed to evaluate whether gut microbiota composition, in addition to clinical biomarkers, could improve the prediction of ... -
Antagonists of Growth Hormone-Releasing Hormone Inhibit the Growth of Pituitary Adenoma Cells by Hampering Oncogenic Pathways and Promoting Apoptotic Signaling
Gesmundo, Iacopo; Granato, Giuseppina; Fuentes-Fayos, Antonio C.; Álvarez, Clara V.; Diéguez, Carlos; Zatelli, Maria Chiara; Congiusta, Noemi; Banfi, Dana; Prencipe, Nunzia; Leone, Sheila; Brunetti, Luigi; Castaño, Justo P.; Luque, Raúl M.; Cai, Renzhi; Sha, Wei; Ghigo, Ezio; Schally, Andrew V.; Granata, Riccarda (MDPI, 2021)Pituitary adenomas (PAs) are intracranial tumors, often associated with excessive hormonal secretion and severe comorbidities. Some patients are resistant to medical therapies; therefore, novel treatment options are needed. ... -
Beta cell functionality and hepatic insulin resistance are major contributors to type 2 diabetes remission and starting pharmacological therapy: from CORDIOPREV randomized controlled trial
Roncero-Ramos, Irene; Gutiérrez Mariscal, Francisco Miguel; Gómez Delgado, Francisco; Villasanta-González, Alejandro; Torres‑Peña, J.D.; Cruz‐Ares, Silvia de la; Rangel Zúñiga, Oriol Alberto; Luque, Raúl M.; Ordovas, José M.; Delgado-Lista, Javier; Pérez-Martínez, Pablo; Camargo García, A.; Alcalá Díaz, Juan Francisco; López-Miranda, José (Elsevier, 2021)In order to assess whether previous hepatic IR (Hepatic-IR fasting) and beta-cell functionality could modulate type 2 diabetes remission and the need for starting glucose- lowering treatment, newly-diagnosed type 2 diabetes ... -
Changes in Splicing Machinery Components Influence, Precede, and Early Predict the Development of Type 2 Diabetes: From the CORDIOPREV Study
Gahete Ortiz, Manuel D.; Río Moreno, Mercedes del; Carpio Camargo, Antonio José; Alcalá Díaz, Juan Francisco; Alors-Pérez, Emilia; Delgado-Lista, Javier; Reyes Pupo, Oscar Gabriel; Ventura, Sebastián; Pérez Martínez, Pablo; Castaño, Justo P.; López Miranda, José; Luque, Raúl M. (Elsevier, 2018)Background: Type-2 diabetes mellitus (T2DM) is a major health problem with increasing incidence, which severely impacts cardiovascular disease. Because T2DM is associated with altered gene expression and aberrant splicing, ... -
Clinical Effectiveness and Safety of Once-Weekly GLP-1 Receptor Agonist Dulaglutide as Add-On to Metformin or Metformin Plus Insulin Secretagogues in Obesity and Type 2 Diabetes
Mirabelli, María; Chiefari, Eusebio; Tocci, Vera; Caroleo, Patrizia; Giuliano, Stefania; Greco, Emanuela; Luque, Raúl M.; Puccio, Luigi; Foti, Daniela Patrizia; Aversa, Antonio; Brunetti, Antonio (MDPI, 2021)Aims and methods: The aim of this monocentric retrospective observational study was to evaluate the 18-month safety and effectiveness of GLP-1 receptor agonist (GLP-1 RA) dulaglutide (DU) 1.5 mg/once weekly as an add-on ... -
Clinical Utility of Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Diagnostic Tool and Potential Therapeutic Target in Prostate Cancer
Jiménez-Vacas, J.M.; Gómez Gómez, Enrique; Montero-Hidalgo, Antonio J.; Herrero-Aguayo, V.; L-López, Fernando; Sánchez-Sánchez, Rafael; Guler, Ipek; Blanca, Ana; Méndez-Vidal, María José; Carrasco, Julia; López-Miranda, José; Requena-Tapia, M.J.; Castaño, Justo P.; Gahete Ortiz, Manuel D.; Luque, Raúl M. (MDPI, 2019)Recent data suggested that plasma Ghrelin O-Acyl Transferase enzyme (GOAT) levels could represent a new diagnostic biomarker for prostate cancer (PCa). In this study, we aimed to explore the diagnostic and prognostic/agg ... -
Comparative Cytotoxic Activity of Hydroxytyrosol and Its Semisynthetic Lipophilic Derivatives in Prostate Cancer Cells
León González, A.J.; Sáez Martínez, Prudencio; Jiménez-Vacas, J.M.; Herrero-Aguayo, V.; Montero-Hidalgo, Antonio J.; Gómez Gómez, Enrique; Madrona, Andrés; Castaño, Justo P.; Espartero, José L.; Gahete Ortiz, Manuel D.; Luque, Raúl M. (MDPI, 2021)A high adherence to a Mediterranean diet has been related to numerous beneficial effects in human health, including a lower incidence and mortality of prostate cancer (PCa). Olive oil is an important source of phenolic ... -
Diabetes Remission Is Modulated by Branched Chain Amino Acids According to the Diet Consumed: From the CORDIOPREV Study
Cardelo, Magdalena P.; Alcalá Díaz, Juan Francisco; Gutiérrez Mariscal, Francisco Miguel; López Moreno, Javier; Villasanta-González, Alejandro; Arenas de Larriva, Antonio P.; Cruz Ares, Silvia de la; Delgado-Lista, Javier; Rodríguez-Cantalejo, Fernando; Luque, Raúl M.; Ordovás, José María; Pérez Martínez, Pablo; Camargo García, A.; López Miranda, José (Wiley, 2021)Scope: Branched Chain Amino Acids (BCAA) plasma levels may be differentially associated with type 2 diabetes mellitus (T2DM) remission through the consumption of the Mediterranean diet (Med) and a low-fat (LF) diet. Methods: ... -
Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study
Río Moreno, Mercedes del; Luque, Raúl M.; Rangel Zúñiga, Oriol Alberto; Alors-Pérez, Emilia; Alcalá Díaz, Juan Francisco; Roncero-Ramos, Irene; Camargo García, A.; Gahete Ortiz, Manuel D.; López-Miranda, José; Castaño, Justo P. (MDPI, 2020)Type-2 diabetes mellitus (T2DM) has become a major health problem worldwide. T2DM risk can be reduced with healthy dietary interventions, but the precise molecular underpinnings behind this association are still incompletely ... -
Does telotristat have a role in preventing carcinoid heart disease?
Herrera-Martínez, Aura D.; Fuentes-Fayos, Antonio C.; Sánchez-Sánchez, Rafael; Montero-Hidalgo, Antonio J .; Sarmento-Cabral, André; Gálvez-Moreno, M. Ángeles; Gahete Ortiz, Manuel D.; Luque, Raúl M. (MDPI, 2024)Carcinoid heart disease (CHD) is a frequent and life-threatening complication in patients with carcinoid tumors. Its clinical management is challenging is some cases since serotonin-induced valve fibrosis leads to heart ... -
Enzima GOAT como biomarcador de diagnóstico del cáncer de próstata
Castaño, Justo P.; Luque, Raúl M.; Gahete Ortiz, Manuel D.; Hormaechea Agulla, Daniel; Requena-Tapia, M.J.; Gómez Gómez, Enrique; Carrasco, Julia; Ibáñez, Alejandro; Moreno, María del Mar; Valero, José (Oficina de Transferencia de Resultados de la Investigación, 2020) -
Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study
Martín-Piedra, Laura; Alcalá Díaz, Juan Francisco; Gutiérrez Mariscal, Francisco Miguel; Arenas de Larriva, Antonio P.; Romero-Cabrera, Juan Luis; Torres‑Peña, J.D.; Caballero-Villarraso, Javier; Luque, Raúl M.; Pérez-Martínez, Pablo; López-Miranda, José; Delgado-Lista, Javier (MDPI, 2021)Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing ... -
Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Novel Potential Biomarker in Gastroenteropancreatic Neuroendocrine Tumors
Herrera-Martínez, Aura D.; Gahete Ortiz, Manuel D.; Sánchez-Sánchez, Rafael; Alors-Pérez, Emilia; Pedraza-Arévalo, Sergio; Serrano-Blanch, Raquel; Martínez-Fuentes, Antonio J.; Castaño, Justo P.; Luque, Raúl M.; Gálvez-Moreno, M. Ángeles (Nature.com, 2018)Objectives: The association between the presence and alterations of the components of the ghrelin system and the development and progression of neuroendocrine tumors (NETs) is still controversial and remains unclear. Methods: ... -
Gold Nanosystems Covered with Doxorubicin/DNA Complexes: A Therapeutic Target for Prostate and Liver Cancer
Giráldez-Pérez, Rosa M.; Grueso, Elia; Montero-Hidalgo, Antonio J.; Luque, Raúl M.; Carnerero, José M.; Carnerero, José M.; Kuliszewska, Edyta; Prado-Gotor, Rafael (MDPI, 2022)Different gold nanosystems covered with DNA and doxorubicin (Doxo) were designed and synthesized for cancer therapy, starting from Au@16-Ph-16 cationic nanoparticles and DNA–Doxo complexes prepared under saturation conditions. ... -
In1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features
Ibáñez-Costa, Alejandro; Gahete Ortiz, Manuel D.; Rivero-Cortés, Esther; Rincón-Fernández, David; Nelson, Richard; Beltrán, Manuel; Riva, Andrés de la; Japón, Miguel A.; Venegas-Moreno, Eva; García-Arnés, Juan A.; Soto-Moreno, Alfonso; Morgan, Jennifer; Tsomaia, Natia; Culler, Michael D.; Diéguez, Carlos; Castaño, Justo P.; Luque, Raúl M.; Gálvez-Moreno, M. Ángeles (Nature.com, 2015)Pituitary adenomas comprise a heterogeneous subset of pathologies causing serious comorbidities, which would benefit from identification of novel, common molecular/cellular biomarkers and therapeutic targets. The ghrelin ... -
Long-term consumption of a mediterranean diet or a low-fat diet on kidney function in coronary heart disease patients: The CORDIOPREV randomized controlled trial
Podadera-Herreros, Alicia; Alcalá Díaz, Juan Francisco; Gutiérrez Mariscal, Francisco Miguel; Jiménez Torres, José; Cruz Ares, Silvia de la; Arenas de Larriva, Antonio P.; Cardelo, Magdalena P.; Torrez-Peña, Juan David; Luque, Raúl M.; Ordovás, José María; Delgado-Lista, Javier; López-Miranda, José; Yubero-Serrano, Elena M. (Elsevier, 2022)Background & aims: Lifestyle and dietary habits influence kidney function, playing an important role in the prevention and development of chronic kidney disease (CKD). The effectiveness of the Mediterranean diet in preserving ... -
LRP10, PGK1 and RPLP0: best reference genes in periprostatic adipose tissue under obesity and prostate cancer conditions
Pérez Gómez, J.M.; Porcel-Pastrana, Francisco; luz borrero, Marina De La; Montero-Hidalgo, Antonio J.; Gómez-Gómez, E.; Herrera-Martínez, Aura D.; Guzmán-Ruiz, Rocío; Malagón, María M.; Gahete Ortiz, Manuel D.; Luque, Raúl M. (MDPI, 2023)Obesity (OB) is a metabolic disorder characterized by adipose tissue dysfunction that has emerged as a health problem of epidemic proportions in recent decades. OB is associated with multiple comorbidities, including some ... -
Metabolic Fingerprint of Acromegaly and its Potential Usefulness in Clinical Practice
Biagetti, Betina; Herance, J.R.; Ferrer, Roser; Aulinas, Anna; Palomino-Schätzlein, Martina; Mesa, Jordi; Castaño, Justo P.; Luque, Raúl M.; Simó, Rafael (MDPI, 2019)Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) levels are the main targets for monitoring acromegaly activity, but they are not in close relationship with the clinical course of the disease and the associated ...