Listar por autor "Luque, Raúl M."
Mostrando ítems 1-14 de 14
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Contribution of somatostatin, cortistatin, their receptors and other peptides to the regulation of growth hormone in primates and mice
Córdoba-Chacón, José (Universidad de Córdoba, Servicio de Publicaciones, 2011)La regulación de la secreción de hormona del crecimiento (GH) se ha considerado clásicamente como resultado de la acción conjunta y coordinada de dos péptidos hipotalámicos: la hormona liberadora de GH (GHRH) y el factor ... -
La desregulación de la maquinaria de splicing está directamente asociada con la agresividad del cáncer de próstata
Montero-Hidalgo, Antonio J. (Universidad de Córdoba, 2022)La desregulación de la expresión de variantes de splicing se ha postulado recientemente como una nueva huella molecular del cáncer. Así, aunque la aparición de variantes de splicing aberrantes (p.ej.: AR-v7, sst5TMD4, etc.) ... -
Enfermedad de Cushing: correlación clínica y molecular
Moreno Moreno, Paloma (Universidad de Córdoba, 2015)La enfermedad de Cushing es la causa más frecuente de síndrome de Cushing endógeno. Se asocia a una morbilidad severa, y en pacientes no tratados o no controlados, se asocia a un aumento de la mortalidad. En general, la ... -
Identification of novel biomarkers and therapeutic targets in the pathological interaction between the dysregulation of the endocrinemetabolic system and prostate cancer
Herrero-Aguayo, V. (Universidad de Córdoba, UCOPress, 2022)Obesity (OB) is a metabolic chronic disease with a growing incidence and elevated morbidities and mortality [1, 2]. OB is also associated with elevated economic costs for the health systems representing a worldwide public ... -
Identification of novel clinical and molecular factors for the diagnosis and aggressiveness of prostate cancer
Gómez Gómez, Enrique (Universidad de Córdoba, UCOPress, 2019)Prostate cancer (PCa) is the most common solid neoplasm in men in developed countries. Unfortunately, the extraordinary heterogeneity and complexity of PCa, together with its phenotypic/clinical variability, strongly ... -
Identification of novel endocrine-metabolic and splicing machinery factors with diagnostic, prognostic and/or therapeutic potential in prostate cancer
Jiménez-Vacas, J.M. (Universidad de Córdoba, UCOPress, 2020)Prostate cancer (PCa) is the tumor pathology with the highest incidence among men in developed countries and represents one of the main causes of cancer-related death in this group. Despite the advances achieved during the ... -
Identification of Novel Markers and Molecular Mechanisms with Diagnostic, Prognostic, and Therapeutic Potential in Brain Tumors
Fuentes-Fayos, Antonio C. (Universidad de Córdoba, UCOPress, 2022)Primary brain tumors represent a highly variable and heterogeneous group of neoplasms (~150 different types) that includes non-malignant and malignant tumors. The most frequent malignant brain tumors are gliomas (representing ... -
Implicación de las características clínico-patológicas, radiológicas y marcadores moleculares en el tratamiento de la acromegalia
Alhambra Expósito, María Rosa (Universidad de Córdoba, UCOPress, 2021)La acromegalia se debe a la producción excesiva de hormona del crecimiento (GH), generalmente por un adenoma hipofisario. El tratamiento primario de elección es el quirúrgico, con unos índices de remisión del 80-90% en ... -
Implication of the alternative splicing process in the development of hepatocelular carcinoma
López Cánovas, Juan Luis (Universidad de Córdoba, UCOPress, 2021)Liver cancer represents a complex and heterogeneous pathology that encompasses several types of malignant tumors with unfavorable characteristics and prognosis, including hepatocellular carcinoma or hepatocarcinoma (HCC). ... -
Metabolic Impact of Adult-Onset, Isolated, Growth Hormone Deficiency (AOiGHD) Due to Destruction of Pituitary Somatotropes
Luque, Raúl M.; Lin, Quig; Córdoba-Chacón, José; Subbaiah, Papasani V.; Buch, Thorsten; Waisman, Ari; Vankelecom, Hugo; Kineman, Rhonda D. (Public Library Of Science (PLOS), 2011)Growth hormone (GH) inhibits fat accumulation and promotes protein accretion, therefore the fall in GH observed with weight gain and normal aging may contribute to metabolic dysfunction. To directly test this hypothesis ... -
Molecular, cellular and anatomopathological study of oral cavity tumors
Sanjuan-Sanjuan, Alba (Universidad de Córdoba, UCOPress, 2022)Oral cavity squamous cell carcinoma (OSCC) continues to be an aggressive disease and a global challenge with a 5-year survival rate of 60%. Depending on the risk factors, surgery and adjuvant radiotherapy +/- chemotherapy ... -
Novel molecular insights on the role of splicing dysregulation in cancer
Alors-Pérez, Emilia (Universidad de Córdoba, UCOPress, 2022)Cancer and tumoral diseases represent one of most serious and complicated public health problems, being one of the leading causes of death in the world. The remarkable variety across cancer types, and the heterogeneity ... -
Somatostatin, cortistatin, ghrelin and their receptors: From an endocrine system to a pleiotropic system of pathophysiologic relevance
Gahete Ortiz, Manuel D. (Universidad de Córdoba, Servicio de Publicaciones, 2010)Somatostatina (SST)/cortistatina (CST) y ghrelina son los más conocidos miembros de dos sistemas complejos formados por un gran número de péptidos y receptores (ssts y GHS-Rs, respectivamente), que, aunque exhiben claras ... -
Valor pronóstico del estudio molecular en la enfermedad de Cushing
Moreno Moreno, Paloma (Universidad de Córdoba, UCOPress, 2022)La enfermedad de Cushing (EC) se origina por un tumor hipofisario secretor de hormona adrenocorticotrópica (ACTH), que suele presentarse en forma de microadenoma en el 95% de los casos. Los tumores hipofisarios secretores ...