Listar por tema "Cell cycle"
Mostrando ítems 1-5 de 5
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Deficiency of Parkinson’s Related Protein DJ-1 Alters Cdk5 Signalling and Induces Neuronal Death by Aberrant Cell Cycle Re-entry
(Springer, 2022)DJ-1 is a multifunctional protein involved in Parkinson disease (PD) that can act as antioxidant, molecular chaperone, protease, glyoxalase, and transcriptional regulator. However, the exact mechanism by which DJ-1 dysfunction ... -
Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells
(Impact Journals, 2015)Galiellalactone (GL) is a fungal metabolite that presents antitumor activities on prostate cancer in vitro and in vivo. In this study we show that GL induced cell cycle arrest in G2/M phase, caspase-dependent apoptosis and ... -
Peroxiredoxin 6 Down-Regulation Induces Metabolic Remodeling and Cell Cycle Arrest in HepG2 Cells
(MDPI, 2019)Peroxiredoxin 6 (Prdx6) is the only member of 1-Cys subfamily of peroxiredoxins in human cells. It is the only Prdx acting on phospholipid hydroperoxides possessing two additional sites with phospholipase A2 (PLA2) and ... -
Regulation of post-translational modifications with pharmacological intervention: autoimmune diseases and cancer
(Universidad de Córdoba, UCOPress, 2022)Post-Translational Modifications are key elements within the cell signalling pathways. These key events promptly reprogram protein's behaviour in presence of environmental alterations in a highly dynamic manner acting as ... -
Role of human Peroxiredoxin 6 (PRDX6) in proliferation, migration, and invasiveness of hepatocarcinoma cell lines
(Universidad de Córdoba, UCOPress, 2023)Reactive oxygen species (ROS) have been considered toxic waste of cellular metabolism and enzymatic activities. However, nowadays it is well-known their tight regulation and the wide range of specific targets that they ...