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Transcriptomic Coordination in the Human Metabolic Network Reveals Links between n-3 Fat Intake, Adipose Tissue Gene Expression and Metabolic Health
(Public Library Of Science (PLOS), 2011)
Understanding the molecular link between diet and health is a key goal in nutritional systems biology. As an alternative to
pathway analysis, we have developed a joint multivariate and network-based approach to analysis ...
Effects of rs7903146 Variation in the Tcf7l2 Gene in the Lipid Metabolism of Three Different Populations
(Public Library Of Science (PLOS), 2012)
Background: TCF7L2 rs7903146 is an important genetic factor predicting type 2 diabetes (T2DM) which has also been linked
to higher cardiovascular risk. To date, there is little information about the additional impact of ...
Glucokinase Regulatory Protein Genetic Variant Interacts with Omega-3 PUFA to Influence Insulin Resistance and Inflammation in Metabolic Syndrome
(Public Library Of Science (PLOS), 2011)
Glucokinase Regulatory Protein (GCKR) plays a central role regulating both hepatic triglyceride and glucose metabolism.
Fatty acids are key metabolic regulators, which interact with genetic factors and influence glucose ...
Proteome from patients with metabolic syndrome is regulated by quantity and quality of dietary lipids
(BioMed Central, 2015)
Background: Metabolic syndrome is a multi-component disorder associated to a high risk of cardiovascular disease.
Its etiology is the result of a complex interaction between genetic and environmental factors, including ...
Influence of Obesity and Metabolic Disease on Carotid Atherosclerosis in Patients with Coronary Artery Disease (CordioPrev Study)
(Public Library of Science, 2016)
Background
Recent data suggest that the presence of associated metabolic abnormalities may be
important modifiers of the association of obesity with a poorer prognosis in coronary heart
disease. We determined the influence ...
Hepatic insulin resistance both in prediabetic and diabetic patients determines postprandial lipoprotein metabolism: from the CORDIOPREV study
(BioMed Central, 2016)
Background/aims: Previous evidences have shown the presence of a prolonged and exaggerated postprandial
response in type 2 diabetes mellitus (T2DM) and its relation with an increase of cardiovascular risk. However, ...
Impact of the Content of Fatty Acids of Oral Fat Tolerance Tests on Postprandial Triglyceridemia: Systematic Review and Meta-Analysis
(MDPI, 2016)
Whether the content of saturated (SFA), monounsaturated (MUFA), and polyunsaturated fatty acids (PUFA) could differently influence postprandial triglycerides (TG) is unknown. We examined possible differences in the ...
In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/β-catenin activation
(American Journal of Physiology, 2012)
The present study investigates the differential effect of two vitamin D receptor agonists, calcitriol and paricalcitol, on human aortic smooth muscle cells calcification in vitro. Human vascular smooth muscle cells were ...
Hypertriglyceridemia Influences the Degree of Postprandial Lipemic Response in Patients with Metabolic Syndrome and Coronary Artery Disease: From the Cordioprev Study
(PLOS, 2014)
Objective
To determine whether metabolic syndrome traits influence the postprandial lipemia response of coronary patients, and whether this influence depends on the number of MetS criteria.
Materials and Methods
1002 ...