Nitrogen Oxyanion-dependent Dissociation of a Two-component Complex That Regulates Bacterial Nitrate Assimilation
Luque-Almagro, Víctor Manuel
Lyall, Verity J.
Ferguson, Stuart J.
Richardson, David J.
Gates, Andrew J.
PublisherAmerican Society for Biochemistry and Molecular Biology
METS:Mostrar el registro METS
PREMIS:Mostrar el registro PREMIS
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Background: Nitrogen oxyanion-responsive two-component regulators that control assimilatory nitrate metabolism in heterotrophic bacteria are poorly characterized. Results: The nasT and nasS genes encode a regulatory complex that dissociates upon sensing nitrate/nitrite, releasing the RNA-binding protein NasT. Conclusion: NasS-NasT is a two-component regulator for nitrate/nitrite perception. Significance: A nitrate/nitrite-sensitive interaction between NasS and NasT has been demonstrated for the first time.