Molecular and Cellular Profiling of Scalp Psoriasis Reveals Differences and Similarities Compared to Skin Psoriasis
Autor
Ruano, Juan
Suárez Fariñas, Mayte
Shemer, Avner
Oliva, Margeaux
Guttman-Yassky, Emma
Krueger, James G.
Editor
Public Library of ScienceFecha
2016Materia
ScalpPsoriasis
Transcriptome analysis
Cytokines
Epidermis
Keratinocytes
T cells
Gene expression
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Scalp psoriasis shows a variable clinical spectrum and in many cases poses a great therapeutic
challenge. However, it remains unknown whether the immune response of scalp psoriasis
differs from understood pathomechanisms of psoriasis in other skin areas. We sought
to determine the cellular and molecular phenotype of scalp psoriasis by performing a comparative
analysis of scalp and skin using lesional and nonlesional samples from 20 Caucasian
subjects with untreated moderate to severe psoriasis and significant scalp involvement
and 10 control subjects without psoriasis. Our results suggest that even in the scalp, psoriasis
is a disease of the inter-follicular skin. The immune mechanisms that mediate scalp psoriasis
were found to be similar to those involved in skin psoriasis. However, the magnitude
of dysregulation, number of differentially expressed genes, and enrichment of the psoriatic
genomic fingerprint were more prominent in skin lesions. Furthermore, the scalp transcriptome
showed increased modulation of several gene-sets, particularly those induced by
interferon-gamma, compared with that of skin psoriasis, which was mainly associated with
activation of TNFα/L-17/IL-22-induced keratinocyte response genes. We also detected differences
in expression of gene-sets involving negative regulation, epigenetic regulation,
epidermal differentiation, and dendritic cell or Th1/Th17/Th22-related T-cell processes.