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Evaluation of a new automated Abbott RealTime MTB RIF/INH assay for qualitative detection of rifampicin/isoniazid resistance in pulmonary and extra-pulmonary clinical samples of Mycobacterium tuberculosis

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Author
Ruiz, Pilar
Causse, Manuel
Vaquero Abellán, Manuel
Casal Román, Manuel
Gutiérrez-Aroca, Juan-Bautista
Publisher
Dovepress
Date
2017
Subject
Abbott RealTime MTB RIF/INH Resistance assay
M. tuberculosis
Mutations
METS:
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PREMIS:
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Abstract
A new automated real-time PCR assay for the detection of rifampicin (RIF) and isoniazid (INH) resistance in Mycobacterium tuberculosis (MTB) was evaluated. A total of 163 clinical samples (128 pulmonary and 35 extra-pulmonary) were processed using four PCR assay kits: Abbott RealTime MTB RIF/INH, Genotype MTBDRplus, Xpert/MTB RIF, and Anyplex MTB/MDR. The results of phenotypic drug-susceptibility testing using BACTECMGIT 960 were used as reference. The sensitivity and specificity of the new Abbott RealTime MTB RIF/ INH assay in comparison with phenotypic testing was 96.3% (95%CI 87.32%–100%) for RIF and 100% (95%CI 99.3%–100%) for INH; the sensitivity was 78.8% (95%CI 66.8%–90.9%) and the specificity was 100% (95%CI 98.9%–100%). The Abbott RealTime MTB RIF/INH test could be a valid method for detecting the most common mutations in strains resistant to RIF and INH.
URI
http://hdl.handle.net/10396/17585
Fuente
Infection and Drug Resistance 10, 463–467 (2017)
Versión del Editor
https://doi.org/10.2147/IDR.S147272
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