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dc.contributor.authorVidal, Ángela
dc.contributor.authorPineda, Carmen
dc.contributor.authorRaya, Ana I.
dc.contributor.authorRíos, Rafael
dc.contributor.authorEspartero, Azahara
dc.contributor.authorMuñoz-Castañeda, Juan R.
dc.contributor.authorRodríguez, Mariano
dc.contributor.authorAguilera Tejero, Escolástico
dc.contributor.authorLópez, Ignacio
dc.date.accessioned2022-03-01T13:04:04Z
dc.date.available2022-03-01T13:04:04Z
dc.date.issued2022
dc.identifier.urihttp://hdl.handle.net/10396/22642
dc.description.abstractIncreased dietary acid load has a negative impact on health, particularly when renal function is compromised. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that is elevated during renal failure. The relationship between metabolic acidosis and FGF23 remains unclear. To investigate the effect of dietary acid load on circulating levels of FGF23, rats with normal renal function and with a graded reduction in renal mass (1/2 Nx and 5/6 Nx) received oral NH4Cl for 1 month. Acid intake resulted in a consistent decrease of plasma FGF23 concentrations in all study groups when compared with their non-acidotic control: 239.3 ± 13.5 vs. 295.0 ± 15.8 pg/mL (intact), 346.4 ± 19.7 vs. 522.6 ± 29.3 pg/mL (1/2 Nx) and 988.0 ± 125.5 vs. 2549.4 ± 469.7 pg/mL (5/6 Nx). Acidosis also decreased plasma PTH in all groups, 96.5 ± 22.3 vs. 107.3 ± 19.1 pg/mL, 113.1 ± 17.3 vs. 185.8 ± 22.2 pg/mL and 504.9 ± 75.7 vs. 1255.4 ± 181.1 pg/mL. FGF23 showed a strong positive correlation with PTH (r = 0.877, p < 0.0001) and further studies demonstrated that acidosis did not influence plasma FGF23 concentrations in parathyroidectomized rats, 190.0 ± 31.6 vs. 215 ± 25.6 pg/mL. In conclusion, plasma concentrations of FGF23 are consistently decreased in rats with metabolic acidosis secondary to increased acid intake, both in animals with intact renal function and with decreased renal function. The in vivo effect of metabolic acidosis on FGF23 appears to be related to the simultaneous decrease in PTH.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceNutrients 14(5), 1041 (2022)es_ES
dc.subjectAcid intakees_ES
dc.subjectFGF23es_ES
dc.subjectPTHes_ES
dc.subjectKidneyes_ES
dc.titleOral Acid Load Down-Regulates Fibroblast Growth Factor 23es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.3390/nu14051041es_ES
dc.relation.projectIDInstituto de Salud Carlos III. PI17/00169es_ES
dc.relation.projectIDInstituto de Salud Carlos III. PI21/00269es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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