• In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/β-catenin activation 

      Martínez-Moreno, Julio M.; Muñoz-Castañeda, Juan R.; Herencia, Carmen; Montes de Oca, Addy; Estepa Nieto, José Carlos; Canalejo, Rocío; Rodríguez-Ortiz, Maria E.; Aguilera Tejero, Escolástico; Canalejo, Antonio; Rodríguez, Mariano; Almadén Peña, Yolanda; Pérez-Martínez, Pablo (American Journal of Physiology, 2012)
      The present study investigates the differential effect of two vitamin D receptor agonists, calcitriol and paricalcitol, on human aortic smooth muscle cells calcification in vitro. Human vascular smooth muscle cells were ...
    • Magnesium Replacement to Protect Cardiovascular and Kidney Damage? Lack of Prospective Clinical Trials 

      Muñoz-Castañeda, Juan R.; Pendón-Ruiz de Mier, María V.; Rodríguez, Mariano; Rodríguez-Ortiz, Maria E. (MDPI, 2018)
      Patients with advanced chronic kidney disease exhibit an increase in cardiovascular mortality. Recent works have shown that low levels of magnesium are associated with increased cardiovascular and all-cause mortality in ...
    • Microvesicles from the plasma of elderly subjects and from senescent endothelial cells promote vascular calcification 

      Alique, Matilde; Ruiz Torres, María Piedad; Bodega, Guillermo; Noci Sánchez, María Victoria; Troyano, Nuria; Bohórquez, Lourdes; Luna, Carlos; Luque, Rafael; Carmona, Andrés; Carracedo Añón, Julia; Ramírez, Rafael (Impact Journals, 2017)
      Vascular calcification is commonly seen in elderly people, though it can also appear in middle-aged subjects affected by premature vascular aging. The aim of this work is to test the involvement of microvesicles (MVs) ...
    • TGF-β Prevents Phosphate-Induced Osteogenesis through Inhibition of BMP and Wnt/β-Catenin Pathways 

      Guerrero Pavón, Fátima; Herencia, Carmen; Almadén Peña, Yolanda; Martínez-Moreno, Julio M.; Montes de Oca, Addy; Rodríguez-Ortiz, Maria E.; Díaz Tocados, Juan Manuel; Florio, Mónica; López, Ignacio; Richards, William G.; Rodríguez Portillo, Mariano; Aguilera Tejero, Escolástico; Muñoz-Castañeda, Juan R. (Public Library of Science, 2014)
      Background: Transforming growth factor-b (TGF-b) is a key cytokine during differentiation of mesenchymal stem cells (MSC) into vascular smooth muscle cells (VSMC). High phosphate induces a phenotypic transformation of ...
    • Vitamin E protects against extraskeletal calcification in uremic rats fed high fat diets 

      Ríos, Rafael; Raya, Ana I.; Pineda Martos, Carmen María; Rodríguez, Mariano; López, Ignacio; Aguilera Tejero, Escolástico (Biomed Central, 2017)
      Background: High fat diets are implicated in the pathogenesis of metabolic syndrome, obesity and renal disease. Previous studies have revealed that high fat diets promote vascular calcification in uremic rats. Moreover, ...