• Hypertriglyceridemia Influences the Degree of Postprandial Lipemic Response in Patients with Metabolic Syndrome and Coronary Artery Disease: From the Cordioprev Study 

  Alcalá Díaz, Juan Francisco; Delgado-Lista, Javier; Pérez-Martínez, Pablo; Quintana-Navarro, Gracia M.; Gómez-Luna, Purificación; Camargo García, A.; Almadén, Yolanda; Caballero, Javier; Marín, Carmen; García-Ríos, Antonio; Tinahones, Francisco J.; Ordovas, José M.; Pérez-Jímenez, Francisco; López-Miranda, José (PLOS, 2014)

  Objective To determine whether metabolic syndrome traits influence the postprandial lipemia response of coronary patients, and whether this influence depends on the number of MetS criteria. Materials and Methods 1002 ...

• Proteome from patients with metabolic syndrome is regulated by quantity and quality of dietary lipids 

  Rangel Zúñiga, Oriol Alberto; Camargo García, A.; Marín, Carmen; Peña Orihuela, Judhit; Pérez-Martínez, Pablo; Delgado-Lista, Javier; González Guardia, Lorena; Yubero-Serrano, Elena M.; Tinahones, Francisco J.; Malagón, María M.; Pérez-Jiménez, Francisco; Roche, Helen M.; López-Miranda, José (BioMed Central, 2015)

  Background: Metabolic syndrome is a multi-component disorder associated to a high risk of cardiovascular disease. Its etiology is the result of a complex interaction between genetic and environmental factors, including ...

• TGF-β Prevents Phosphate-Induced Osteogenesis through Inhibition of BMP and Wnt/β-Catenin Pathways 

  Guerrero Pavón, Fátima; Herencia, Carmen; Almadén Peña, Yolanda; Martínez-Moreno, Julio M.; Montes de Oca, Addy; Rodríguez-Ortiz, Maria E.; Díaz Tocados, Juan Manuel; Florio, Mónica; López, Ignacio; Richards, William G.; Rodríguez Portillo, Mariano; Aguilera Tejero, Escolástico; Muñoz-Castañeda, Juan R. (Public Library of Science, 2014)

  Background: Transforming growth factor-b (TGF-b) is a key cytokine during differentiation of mesenchymal stem cells (MSC) into vascular smooth muscle cells (VSMC). High phosphate induces a phenotypic transformation of ...

• In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/β-catenin activation 

  Martínez-Moreno, Julio M.; Muñoz-Castañeda, Juan R.; Herencia, Carmen; Montes de Oca, Addy; Estepa Nieto, José Carlos; Canalejo, Rocío; Rodríguez-Ortiz, Maria E.; Aguilera Tejero, Escolástico; Canalejo, Antonio; Rodríguez, Mariano; Almadén Peña, Yolanda; Pérez-Martínez, Pablo (American Journal of Physiology, 2012)

  The present study investigates the differential effect of two vitamin D receptor agonists, calcitriol and paricalcitol, on human aortic smooth muscle cells calcification in vitro. Human vascular smooth muscle cells were ...

• Magnesium Inhibits Wnt/β-Catenin Activity and Reverses the Osteogenic Transformation of Vascular Smooth Muscle Cells 

  Montes de Oca, Addy; Guerrero Pavón, Fátima; Martínez-Moreno, Julio M.; Madueño, Juan A.; Herencia, Carmen; Peralta, Alan; Almadén Peña, Yolanda; López, Ignacio; Aguilera Tejero, Escolástico; Gundlach, Kristina; Büchel, Janine; Peter, Mirjam E.; Passlick-Deetjen, Jutta; Rodríguez Portillo, Mariano; Muñoz-Castañeda, Juan R. (Public Library of Science, 2014)

  Magnesium reduces vascular smooth muscle cell (VSMC) calcification in vitro but the mechanism has not been revealed so far. This work used only slightly increased magnesium levels and aimed at determining: a) whether ...

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