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dc.contributor.authorPriolo, Vito
dc.contributor.authorMartínez-Orellana, Pamela
dc.contributor.authorGrazia Pennisi, Maria
dc.contributor.authorRaya Bermúdez, Ana Isabel
dc.contributor.authorJurado Tarifa, Estefanía
dc.contributor.authorMasucci, Marisa
dc.contributor.authorDonato, Giulia
dc.contributor.authorBruno, Federica
dc.contributor.authorCastelli, Germano
dc.contributor.authorSolano-Gallego, Laia
dc.date.accessioned2022-09-09T08:24:20Z
dc.date.available2022-09-09T08:24:20Z
dc.date.issued2022
dc.identifier.urihttp://hdl.handle.net/10396/23851
dc.description.abstractDogs are the main reservoir of Leishmania infantum and display different immunological patterns correlating with the progression of infection to disease. Data about feline L. infantum adaptive immune response are scant. This study aimed to compare the prevalence and immune response in cats and dogs from the same endemic area of canine leishmaniosis. Stray cats (109) and rescued dogs (59) from Córdoba (Spain) were enrolled. Data about their exposure to L. infantum were analyzed by detection of parasite DNA, measurements of Leishmania-specific interferon-γ (whole blood assay in 57 cats and 29 dogs), and antibodies (enzyme-linked immunosorbent assay and immunofluorescence antibody test). An overall L. infantum prevalence of 30.5% in dogs and 30% in cats were found according to serology and PCR tests. Prevalence was 44.8% in dogs and 35.1% in cats tested also for interferon-γ production. Dogs showed higher anti-L. infantum antibody levels compared to cats. More than one-third of cats had contact with or were infected by L. infantum and they may contribute to the endemicity of leishmaniosis in the investigated region. The immunopathogenesis of feline L. infantum infection has similarities with dogs but cats show a lower level of adaptive immune response compared to dogs.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceVeterinary Sciences 9(9), 482 (2022)es_ES
dc.subjectLeishmaniosises_ES
dc.subjectFelinees_ES
dc.subjectCaninees_ES
dc.subjectIFN-yes_ES
dc.subjectWhole blood assayes_ES
dc.subjectPCRes_ES
dc.subjectFeline immunodeficiency viruses_ES
dc.subjectPrevalencees_ES
dc.subjectELISAes_ES
dc.subjectIFATes_ES
dc.titleLeishmania infantum Specific Humoral and Cellular Immune Responses in Cats and Dogs: A Comparative Cross-Sectional Studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.3390/vetsci9090482es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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