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dc.contributor.authorGómez-Melero, Sara
dc.contributor.authorCaballero-Villarraso, Javier
dc.date.accessioned2023-05-17T08:28:46Z
dc.date.available2023-05-17T08:28:46Z
dc.date.issued2023
dc.identifier.issn2073-4468
dc.identifier.urihttp://hdl.handle.net/10396/25279
dc.description.abstractThe CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved in a wide range of biological processes. When CCR6 binds to its sole ligand CCL20, a signaling network is produced. This pathway is implicated in mechanisms related to many diseases, such as cancer, psoriasis, multiple sclerosis, HIV infection or rheumatoid arthritis. The CCR6/CCL20 axis plays a fundamental role in immune homeostasis and activation. Th17 cells express the CCR6 receptor and inflammatory cytokines, including IL-17, IL-21 and IL-22, which are involved in the spread of inflammatory response. The CCL20/CCR6 mechanism plays a crucial role in the recruitment of these pro-inflammatory cells to local tissues. To date, there are no drugs against CCR6 approved, and the development of small molecules against CCR6 is complicated due to the difficulty in screenings. This review highlights the potential as a therapeutic target of the CCR6 receptor in numerous diseases and the importance of the development of antibodies against CCR6 that could be a promising alternative to small molecules in the treatment of CCR6/CCL20 axis-related pathologies.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceAntibodies 12(2), 30 (2023)es_ES
dc.subjectCCR6es_ES
dc.subjectTherapeutic antibodieses_ES
dc.subjectInflammatory diseaseses_ES
dc.subjectTreatmentes_ES
dc.titleCCR6 as a potential target for therapeutic antibodies for the treatment of inflammatory diseaseses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.3390/antib12020030es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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