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Comparative study between the diagnostic effectiveness of brain SPECT with [123I]Ioflupane and [123I]MIBG scintigraphy in multiple system atrophy
dc.contributor.author | Villena-Salinas, Javier | |
dc.contributor.author | Ortega-Lozano, Simeón José | |
dc.contributor.author | Amrani-Raissouni, Tomader | |
dc.contributor.author | Agüera Morales, Eduardo | |
dc.contributor.author | Caballero-Villarraso, Javier | |
dc.date.accessioned | 2024-01-16T12:46:38Z | |
dc.date.available | 2024-01-16T12:46:38Z | |
dc.date.issued | 2024 | |
dc.identifier.issn | 2227-9059 | |
dc.identifier.uri | http://hdl.handle.net/10396/26572 | |
dc.description.abstract | Background: Multiple system atrophy (MSA) is a neurodegenerative disease. It has a fast progression, so early diagnosis is decisive. Two functional imaging tests can be involved in its diagnosis: [123I]Ioflupane SPECT and [123I]MIBG scintigraphy. Our aim is to comparatively analyze the diagnostic performance of both techniques. Methods: 46 patients (24 males and 22 females) with MSA underwent [123I]Ioflupane SPECT and [123I]MIBG scintigraphy. In each of these techniques, qualitative assessment was compared with quantitative assessment. Results: SPECT visual assessment was positive in 93.5% of subjects (S = 95.24%; PPV = 93.02%). A cut-off of 1.363 was established for overall S/O index (S = 85.7%, E = 100%). Visual assessment of scintigraphy was positive in 73.1% (S = 78.57%, PPV = 94.29%). For the delayed heart/medistinum ratio (HMR) a cut-off of 1.43 (S = 85.3, E = 100%) was obtained. For each unit increase in delayed HMR, the suspicion of MSA increased by 1.58 (OR = 1.58, p < 0.05). The quantitative assessment showed an association with the visual assessment for each technique (p < 0.05). Conclusions: Both tests are useful in MSA diagnosis. Comparatively, we did not observe a clear superiority of either. Striatal and myocardial deterioration do not evolve in parallel. Qualitative assessment is crucial in both techniques, together with the support of quantitative analysis. Delayed HMR shows a direct relationship with the risk of MSA. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.source | Biomedicines, 12(1), 102 (2024) | es_ES |
dc.subject | Multiple system atrophy | es_ES |
dc.subject | Dysautonomia | es_ES |
dc.subject | Diagnostic accuracy | es_ES |
dc.subject | Ioflupane-123 | es_ES |
dc.subject | Meta-iodobenzylguanidine-123 | es_ES |
dc.title | Comparative study between the diagnostic effectiveness of brain SPECT with [123I]Ioflupane and [123I]MIBG scintigraphy in multiple system atrophy | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/biomedicines12010102 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |