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Allele/haplotype variation in the MHC-DQA2 gene in Spanish sheep and its association with footrot susceptibility
dc.contributor.author | Anaya, Gabriel | |
dc.contributor.author | Negro, S. | |
dc.contributor.author | Zhou, H. | |
dc.contributor.author | Hickford, J. | |
dc.contributor.author | Molina, Antonio | |
dc.date.accessioned | 2024-01-17T12:02:18Z | |
dc.date.available | 2024-01-17T12:02:18Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0034-5288 | |
dc.identifier.uri | http://hdl.handle.net/10396/26591 | |
dc.description.abstract | Footrot is a contagious disease that affects the hoof of sheep and other ungulates. The severity of the disease varies from a slight limp to the death of the individual due to injuries that prevent them from feeding. Variants of the Major Histocompatibility Complex (MHC)-DQA2 gene (MHC-DQA2) have been associated with a greater or lesser susceptibility to footrot in Greek, New Zealand and German sheep. In this study, variation in ovine MHC-DQA2, the absence or presence of footrot and the severity of infection was analysed in 117 Spanish Merino, Black Merino and Churra Lebrijana sheep. A total of 21 alleles/haplotypes and 65 genotypes were found with different frequencies in these breeds. As found in other studies, the MHC-DQA2 allele *1101 appeared to be associated with increased susceptibility to footrot, while allele *1201 appeared to be associated with decreased susceptibility. Overall this would suggest the ovine MHC plays a role in controlling susceptibility to footrot infection and that there are breed differences in susceptibility. Sheep might therefore be able to be selected by their MHC-DQA2 alleles/haplotypes to reduce the incidence of the disease in flocks. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | spa | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.source | Research in Veterinary Science; 141, 190–194 (2021) | es_ES |
dc.subject | Footrot | es_ES |
dc.subject | Spanish sheep | es_ES |
dc.subject | DQA2 | es_ES |
dc.subject | Footrot gene-marker score | es_ES |
dc.title | Allele/haplotype variation in the MHC-DQA2 gene in Spanish sheep and its association with footrot susceptibility | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.rvsc.2021.10.020 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |