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Evaluation of toxicological endpoints in female zebrafish after bisphenol A exposure
dc.contributor.author | Molina López, Ana María | |
dc.contributor.author | Abril, Nieves | |
dc.contributor.author | Morales-Prieto, N. | |
dc.contributor.author | García-Monterde, J. | |
dc.contributor.author | Lora-Benítez, Antonio Jesús | |
dc.contributor.author | Ayala-Soldado, Nahúm | |
dc.contributor.author | Moyano Salvago, M. Rosario | |
dc.date.accessioned | 2024-01-30T13:05:01Z | |
dc.date.available | 2024-01-30T13:05:01Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0278-6915 | |
dc.identifier.uri | http://hdl.handle.net/10396/26844 | |
dc.description.abstract | Given the importance of bisphenol A (BPA) as a xenoestrogen and its potential effects on human and animal, we evaluated BPA exposure's short-term effects on follicular development, yolk protein vitellogenin (VTG) production and aromatase expression in female zebrafish. Histological modifications were observed along with increased presence of atretic follicles. Whole-body VTG concentration increased with the dose of BPA exposure. In contrast, expression of Cyp19a mRNA in the ovaries of BPA-exposed fish exhibited an apparent non- monotonic response curve, marked by downregulation at 1 μg/L BPA, upregulation at 10 μg/L BPA, and a return to downregulation at 100 μg/L BPA and higher doses. Ovaries only exhibited significant increases in follicular atresia and VTG concentration after exposure to 100 μg/L BPA and higher doses. Ovarian histopathology, ar- omatase Cyp19a transcript levels and whole-body VTG protein abundance may be good biomarkers for early detection of environmental BPA exposure | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/ | es_ES |
dc.source | Molina, A., Abril, N., Morales-Prieto, N., García-Monterde, J., Lora-Benítez, A., Ayala-Soldado, N., & Moyano, R. (2018). Evaluation of toxicological endpoints in female zebrafish after bisphenol A exposure. Food and Chemical Toxicology, 112, 19-25. https://doi.org/10.1016/j.fct.2017.12.026 | es_ES |
dc.subject | Bisphenol A | es_ES |
dc.subject | Zebrafish | es_ES |
dc.subject | Aromatase | es_ES |
dc.subject | Vitellogenin | es_ES |
dc.subject | Atretic follicle | es_ES |
dc.title | Evaluation of toxicological endpoints in female zebrafish after bisphenol A exposure | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.fct.2017.12.026 | es_ES |
dc.relation.projectID | Junta de Andalucía. P09-AGR-514 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |