Myoepithelial cells in canine mammary tumours
Autor
Sánchez-Céspedes, Raquel
Millán, Yolanda
Guil-Luna, Silvia
Reymundo, Carlos
Espinosa de los Monteros, Antonio
Martín de las Mulas González-Albo, Juana
Editor
ElsevierFecha
2016Materia
CanineIdentification
Prognosis
Mammary gland
Myoepithelial cells
Tumour
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Mammary tumours are the most common neoplasms of female dogs. Compared to mammary tumours of humans and cats, myoepithelial (ME) cell involvement is common in canine mammary tumours (CMT) of any subtype. Since ME cell involvement in CMT influences both histogenetic tumour classification and prognosis, correct identification of ME cells is important. This review describes immunohistochemical methods for identification of canine mammary ME cells used in vivo. In addition, phenotypic and genotypic methods to isolate ME cells for in vitro studies to analyse tumour-suppressor protein production and gene expression are discussed. The contribution of ME cells to both histogenetic classifications and the prognosis of CMT is compared with other species and the potential use of ME cells as a method to identify carcinoma in situ is discussed.
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Embargado hasta 06/02/2044