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dc.contributor.authorOteros, José
dc.contributor.authorBartusel, Elke
dc.contributor.authorAlessandrini, Francesca
dc.contributor.authorNúñez, Andrés
dc.contributor.authorMoreno, Diego
dc.contributor.authorBehrendt, Heidrun
dc.contributor.authorSchmidt-Weber, Carsten
dc.contributor.authorTraidl-Hoffmann, Claudia
dc.contributor.authorButers, Jeroen
dc.date.accessioned2024-02-08T21:25:47Z
dc.date.available2024-02-08T21:25:47Z
dc.date.issued2018
dc.identifier.issn0091-6749
dc.identifier.urihttp://hdl.handle.net/10396/27339
dc.description.abstractBackground: Endotoxin (LPS) released from gram-negative bacteria causes strong immunologic and inflammatory effects and, when airborne, can contribute to respiratory conditions, such as allergic asthma. Objectives: We sought to identify the source of airborne endotoxin and the effect of this endotoxin on allergic sensitization. Methods: We determined LPS levels in outdoor air on a daily basis for 4 consecutive years in Munich (Germany) and Davos (Switzerland). Air was sampled as particulate matter (PM) greater than 10 mm (PM > 10) and PM between 2.5 and 10 mm. LPS levels were determined by using the recombinant Factor C assay. Results: More than 60% of the annual endotoxin exposure was detected in the PM > 10 fraction, showing that bacteria do not aerosolize as independent units or aggregates but adhered to large particles. In Munich 70% of annual exposure was detected between June 12th and August 28th. Multivariate modeling showed that endotoxin levels could be explained by phenological parameters (ie, plant growth). Indeed, days with high airborne endotoxin levels correlated well with the amount of Artemisia pollen in the air. Pollen collected from plants across Europe (100 locations) showed that the highest levels of endotoxin were detected on Artemisia vulgaris (mugwort) pollen, with little on other pollen. Microbiome analysis showed that LPS concentrations on mugwort pollen were related to the presence of Pseudomonas species and Pantoea species communities. In a mouse model of allergic disease, the presence of LPS on mugwort pollen was needed for allergic sensitization.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherAmerican Academy of Allergy, Asthma & Immunologyes_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceOteros, J., Bartusel, E., Alessandrini, F., Nunez, A., Moreno, D. A., Behrendt, H., Schmidt-Weber, C., Traidl-Hoffmann, C., & Buters, J. (2019). Artemisia pollen is the main vector for airborne endotoxin. Journal of Allergy and Clinical Immunology, 143(1), 369-377. http://dx.doi.org/10.1016/j.jaci.2018.05.040es_ES
dc.subjectEndotoxines_ES
dc.subjectAmbientes_ES
dc.subjectBacteriaes_ES
dc.subjectPollenes_ES
dc.subjectGram-negativees_ES
dc.subjectRecombinant Factor ces_ES
dc.subjectDavoses_ES
dc.subjectMuniches_ES
dc.subjectArtemisia specieses_ES
dc.subjectMicrobiomees_ES
dc.subjectMouse modeles_ES
dc.subjectAllergyes_ES
dc.subjectLPSes_ES
dc.subjectSourcees_ES
dc.subjectPM10es_ES
dc.subjectPM2.5es_ES
dc.titleArtemisia pollen is the main vector for airborne endotoxines_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.jaci.2018.05.040es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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