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Effects of Biological Therapies on Molecular Features of Rheumatoid Arthritis
(MDPI, 2020)
Rheumatoid arthritis (RA) is an autoimmune and chronic inflammatory disease primarily affecting the joints, and closely related to specific autoantibodies that mostly target modified self-epitopes. Relevant findings in the ...
Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance
(MDPI, 2021)
Evidence from observational and in vitro studies suggests that insulin growth-factor-binding protein type 2 (IGFBP2) is a promising protein in non-communicable diseases, such as obesity, insulin resistance, metabolic ...
Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study
(MDPI, 2019)
Oral diabetes-specific nutritional supplements (ONS-D) induce favourable postprandial
responses in subjects with type 2 diabetes (DM2), but they have not been correlated yet with incretin
release and subjective appetite ...
Magnesium Replacement to Protect Cardiovascular and Kidney Damage? Lack of Prospective Clinical Trials
(MDPI, 2018)
Patients with advanced chronic kidney disease exhibit an increase in cardiovascular
mortality. Recent works have shown that low levels of magnesium are associated with increased
cardiovascular and all-cause mortality in ...
Impact of the Content of Fatty Acids of Oral Fat Tolerance Tests on Postprandial Triglyceridemia: Systematic Review and Meta-Analysis
(MDPI, 2016)
Whether the content of saturated (SFA), monounsaturated (MUFA), and polyunsaturated fatty acids (PUFA) could differently influence postprandial triglycerides (TG) is unknown. We examined possible differences in the ...
Calcifediol Treatment and Hospital Mortality Due to COVID-19: A Cohort Study
(MDPI, 2021)
Context. Calcifediol has been proposed as a potential treatment for COVID-19 patients. Objective: To compare the administration or not of oral calcifediol on mortality risk of patients hospitalized because of COVID-19. ...
Quality and Quantity of Protein Intake Influence Incidence of Type 2 Diabetes Mellitus in Coronary Heart Disease Patients: From the CORDIOPREV Study
(MDPI, 2021)
Evidence suggests that enriching a diet with plant-based proteins could reduce the risk of developing type 2 diabetes mellitus. In the present work, we evaluated the association between the change in plant protein intake ...
Coenzyme Q10 and Cardiovascular Diseases
(MDPI, 2021)
Coenzyme Q10 (CoQ10), which plays a key role in the electron transport chain by providing an adequate, efficient supply of energy, has another relevant function as an antioxidant, acting in mitochondria, other cell ...
Alternative Foods in Cardio-Healthy Dietary Models That Improve Postprandial Lipemia and Insulinemia in Obese People
(MDPI, 2021)
Obesity is one of the major health problems worldwide. Following healthy dietary patterns can be difficult in some countries due to the lack of availability of certain foods; thus, alternative foods are needed. Our aim was ...
Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities
(MDPI, 2020)
Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin resistance response in non-adipose ...