Listar Departamento de Anatomía y Anatomía Patológica Comparadas y Toxicología por autor "514a3a02-a485-4800-9df2-85f7b39c3138"
Mostrando ítems 1-9 de 9
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Evaluation of Th1/Th2, regulatory cytokines and transcriptional factor FoxP3 in sheep immunized with a partially protective and non-protective vaccine and challenged with Fasciola hepatica
Ruiz-Campillo, María Teresa; Pacheco, I.L.; Abril, Nieves; Bautista Pérez, María José; Martínez Moreno, Álvaro; Martínez-Moreno, Francisco Javier; Buffoni Perazzo, Leandro; Pérez, J.; Molina-Hernández, Verónica; Zafra Leva, Rafael (BMC (Springer), 2024)Gene expression for Th1/Th2 cytokines (IL-4 and IFN-ɣ), regulatory cytokines (TGF-β and IL-10) and the transcriptional factor FoxP3 was analyzed in the liver and hepatic lymph nodes (HLN) from sheep immunized with partially ... -
Evaluation of toxicological endpoints in female zebrafish after bisphenol A exposure
Molina López, Ana María; Abril, Nieves; Morales-Prieto, N.; García-Monterde, J.; Lora-Benítez, Antonio Jesús; Ayala-Soldado, Nahúm; Moyano Salvago, M. Rosario (Elsevier, 2018)Given the importance of bisphenol A (BPA) as a xenoestrogen and its potential effects on human and animal, we evaluated BPA exposure's short-term effects on follicular development, yolk protein vitellogenin (VTG) production ... -
Expresión génica de IL4 e INFΓ en hígado y nódulo linfático hepático en ovejas vacunadas con CL1 infectadas con Fasciola hepática
Pacheco, I.L.; Abril, Nieves; Morales-Prieto, N.; Bautista Pérez, María José; Ruiz, M.Teresa; Zafra Leva, Rafael; Escamilla, Alejandro; Martínez-Moreno, Álvaro; Pérez, José (2017-11-30) -
Fasciola hepatica induces Foxp3 T cell, proinflammatory and regulatory cytokine overexpression in liver from infected sheep during early stages of infection
Pacheco, Isabel; Abril, Nieves; Zafra Leva, Rafael; Molina-Hernández, Verónica; Morales‑Prieto2, Noelia; Bautista Pérez, María José; Ruiz-Campillo, María Teresa; Pérez Caballero, Raúl; Martínez Moreno, Álvaro; Pérez, José (Springer, 2018)The expression of T regulatory cells (Foxp3), regulatory (interleukin [IL]-10 and transforming growth factor beta [TGF-β]) and proinflammatory (tumor necrosis factor alpha [TNF-α] and interleukin [IL]-1β) cytokines was ... -
Fasciola hepatica primoinfections and reinfections in sheep drive distinct Th1/Th2/Treg immune responses in liver and hepatic lymph node at early and late stages
Ruiz-Campillo, María Teresa; Barrero‑Torres, Diana María; Abril, Nieves; Pérez, José; Zafra Leva, Rafael; Buffoni Perazzo, Leandro; Martínez Moreno, Álvaro; Martínez-Moreno, Francisco Javier; Molina-Hernández, Verónica (Springer, 2023)The expression of proinflammatory (IL-1β, IFN-γ, TNF-α) and regulatory (IL-10, TGF-β, IL-4) cytokines, as well as the transcription factor FoxP3, was quantified in the liver and hepatic lymph node (HLN) of sheep primoinfected ... -
Hypothalamic-pituitary-ovarian axis perturbation in the basis of bisphenol A (BPA) reproductive toxicity in female zebrafish (Danio rerio)
Molina López, Ana María; Abril, Nieves; Morales-Prieto, N.; García-Monterde, J.; Ayala-Soldado, Nahúm; Lora-Benítez, Antonio Jesús; Moyano Salvago, M. Rosario (Elsevier, 2018)Thousands of safety-related studies have been published on bisphenol A (BPA), an ubiquitous environmental pollutant with estrogenic activity and many other potential biological effects. In recent years, BPA exposure has ... -
Identification of reference genes for real-time PCR cytokine gene expression studies in sheep experimentally infected with Fasciola hepatica
Pacheco, I.L.; Abril, Nieves; Zafra Leva, Rafael; Morales-Prieto, N.; Molina Hernández, Verónica; Ruiz, M.T.; Pérez Caballero, Raúl; Martínez-Moreno, Álvaro; Pérez, José (Nature.com, 2019)The aim of this study was to validate reference genes for gene normalisation using qRT-PCR in hepatic lymph nodes (HLN) and livers from sheep infected with Fasciola hepatica during early and late stages of infection. To ... -
Proteomic profile of the effects of low-dose bisphenol A on zebrafish ovaries
Molina López, Ana María; Abril, Nieves; Lora Benítez, Antonio; Huertas-Abril, Paula V.; Ayala Soldado, Nahúm; Blanco, Carmen; Moyano Salvago, M. Rosario (Elsevier, 2021)Human exposure to bisphenol-A (BPA) is largely unavoidable because BPA is an environmental contaminant found in soil, water, food and indoor dust. The safety of authorized BPA amounts in consumer products is under question ... -
Transcriptional and biochemical changes in mouse liver following exposure to a metal/drug cocktail. Attenuating effect of a selenium-enriched diet
Huertas-Abril, Paula V; Prieto-Álamo, M. José; Jurado, Juan; Pérez, José; Molina-Hernández, Verónica; García-Barrera, Tamara; Abril, Nieves (Elsevier, 2024)Real-life pollution usually involves simultaneous co-exposure to different chemicals. Metals and drugs are frequently and abundantly released into the environment, where they interact and bioaccumulate. Few studies analyze ...