Listar Departamento de Anatomía y Anatomía Patológica Comparadas y Toxicología por autor "d665ad78-56b2-40a7-8ed8-97209a6a5fd3"
Mostrando ítems 1-14 de 14
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A Partially Protective Vaccine for Fasciola hepatica Induced Degeneration of Adult Flukes Associated to a Severe Granulomatous Reaction in Sheep
Molina Hernández, Verónica; Ruiz-Campillo, María Teresa; Martínez-Moreno, Francisco Javier; Buffoni Perazzo, Leandro; Martínez-Moreno, Álvaro; Zafra Leva, Rafael; Escamilla, Alejandro; Pérez Caballero, Raúl; Pérez Arévalo, José (MDPI, 2021)Fasciolosis is an important economic disease of livestock. There is a global interest in the development of protective vaccines since current anthelmintic therapy is no longer sustainable. A better knowledge of the ... -
Caracterización de macrófagos peritoneales de ovejas en fases tempranas de infección experimental con fasciola hepática
Zafra Leva, Rafael; Pacheco, I.L.; Escamilla, Alejandro; Caballero, R.; Buffoni Perazzo, Leandro; Molina Hernández, Verónica; Martínez-Moreno, Álvaro; Pérez, José; Ruiz-Campillo, María Teresa (Universidad de Córdoba. Departamento de Anatomía y Anatomía Patológica Comparadas, 2016) -
Characterization of dendritic cells and follicular dendritic cells in the hepatic lymph nodes and liver of sheep experimentally infected with Fasciola hepatica
Ruiz-Campillo, María Teresa; Molina-Hernández, Verónica; Bautista Pérez, María José; Pacheco, I.L.; Zafra Leva, Rafael; Buffoni Perazzo, Leandro; Martínez-Moreno, Francisco Javier; Martínez Moreno, Álvaro; Pérez, José (Springer, 2020)Fasciola hepatica has been shown to have a high capacity for immunomodulation of the host response, making the development of protective vaccines extremely difficult. One of these immunomodulation mechanisms is the impairment ... -
Comparative dynamics of peritoneal cell immunophenotypes in sheep during the early and late stages of the infection with Fasciola hepatica by flow cytometric analysis
Pérez Caballero, Raúl; Martínez-Moreno, Francisco Javier; Zafra Leva, Rafael; Molina-Hernández, Verónica; Pacheco, I.L.; Ruiz-Campillo, María Teresa; Escamilla, Alejandro; Pérez, José; Martínez Moreno, Álvaro; Buffoni Perazzo, Leandro (Springer, 2018)Background: The peritoneal cell populations (PCP) are thought to play a crucial role during the early immune response in Fasciola hepatica infection while newly excysted juveniles (NEJ) are migrating in the peritoneal ... -
Distribution of Foxp3+ T cells in the liver and hepatic lymph nodes of goats and sheep experimentally infected with Fasciola hepatica
Escamilla, Alejandro; Zafra Leva, Rafael; Pérez, José; McNeilly, T.N.; Pacheco, I.L.; Buffoni Perazzo, Leandro; Martínez-Moreno, Francisco Javier; Molina Hernández, Verónica; Martínez-Moreno, Álvaro (Elsevier, 2016)Foxp3 regulatory T cells (Tregs) are now considered to play a key role in modulation of immune responses during parasitic helminth infections. Immunomodulation is a key factor in Fasciola hepatica infection; however, the ... -
Evaluation of Th1/Th2, regulatory cytokines and transcriptional factor FoxP3 in sheep immunized with a partially protective and non-protective vaccine and challenged with Fasciola hepatica
Ruiz-Campillo, María Teresa; Pacheco, I.L.; Abril, Nieves; Bautista Pérez, María José; Martínez Moreno, Álvaro; Martínez-Moreno, Francisco Javier; Buffoni Perazzo, Leandro; Pérez, J.; Molina-Hernández, Verónica; Zafra Leva, Rafael (BMC (Springer), 2024)Gene expression for Th1/Th2 cytokines (IL-4 and IFN-ɣ), regulatory cytokines (TGF-β and IL-10) and the transcriptional factor FoxP3 was analyzed in the liver and hepatic lymph nodes (HLN) from sheep immunized with partially ... -
Expression of free radicals by peritoneal cells of sheep during the early stages of Fasciola hepatica infection
Pérez Caballero, Raúl; Buffoni Perazzo, Leandro; Martínez-Moreno, Francisco Javier; Zafra Leva, Rafael; Molina-Hernández, Verónica; Pérez, José; Martínez Moreno, Álvaro (Springer, 2018)Background: The majority of vaccination studies against infection with F. hepatica in a natural host have been conducted at the late stage of the infection when the host's immune response is already immunomodulated by the ... -
Fasciola hepatica primoinfections and reinfections in sheep drive distinct Th1/Th2/Treg immune responses in liver and hepatic lymph node at early and late stages
Ruiz-Campillo, María Teresa; Barrero‑Torres, Diana María; Abril, Nieves; Pérez, José; Zafra Leva, Rafael; Buffoni Perazzo, Leandro; Martínez Moreno, Álvaro; Martínez-Moreno, Francisco Javier; Molina-Hernández, Verónica (Springer, 2023)The expression of proinflammatory (IL-1β, IFN-γ, TNF-α) and regulatory (IL-10, TGF-β, IL-4) cytokines, as well as the transcription factor FoxP3, was quantified in the liver and hepatic lymph node (HLN) of sheep primoinfected ... -
Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine development
Flores Velazquez, Luis Miguel; Ruiz-Campillo, María Teresa; Herrera-Torres, Guillem; Martínez Moreno, Álvaro; Martínez-Moreno, Francisco Javier; Zafra Leva, Rafael; Buffoni Perazzo, Leandro; Rufino-Moya, Pablo José; Molina-Hernández, Verónica; Pérez, José (Frontiers, 2023)Fasciola hepatica has a worldwide distribution causing important economic losses in animal production industry. Human fasciolosis is considered an emerging zoonosis in areas of Andean America, Asia, and Africa. The control ... -
Identification of protective peptides of Fasciola hepatica-derived cathepsin L1 (FhCL1) in vaccinated sheep by a linear B-cell epitope mapping approach
Buffoni Perazzo, Leandro; Garza-Cuartero, Laura; Pérez Caballero, Raúl; Zafra Leva, Rafael; Martínez-Moreno, Francisco Javier; Molina-Hernández, Verónica; Pérez, José; Martínez Moreno, Álvaro; Mulcahy, Grace (Springer, 2020)Background: Fasciolosis is one of the most important parasitic diseases of livestock. The need for better control strategies gave rise to the identification of various vaccine candidates. The recombinant form of a member ... -
Liver Histopathological and Immunohistochemical Evaluation from Fasciola hepatica Experimentally Infected and Reinfected Sheep
Herrera-Torres, Guillem; Ruiz-Campillo, María Teresa; Bautista Pérez, María José; Martínez-Moreno, Francisco Javier; Zafra Leva, Rafael; Buffoni Perazzo, Leandro; Rufino-Moya, Pablo José; Martínez Moreno, Álvaro; Molina-Hernández, Verónica; Pérez, José (MDPI, 2024)Fasciolosis is an important economic disease of livestock. There is a global interest in the development of protective vaccines since the current anthelmintic therapy is no longer sustainable. A better knowledge of the ... -
Serosurveillance of Trichinella sp. in wild boar and Iberian domestic suids in Mediterranean ecosystems of southwestern Spain
Buffoni Perazzo, Leandro; Cano Terriza, David; Jiménez-Martín, Débora; Jiménez-Ruiz, Saúl; Martínez Moreno, Álvaro; Martínez-Moreno, Francisco Javier; Zafra Leva, Rafael; Pérez Caballero, Raúl; Risalde, M.A.; Gómez-Guillamón, Félix; García-Bocanegra, Ignacio (Wiley, 2023)Aims: A cross-sectional study was carried out to assess the seroprevalence and risk factors associated with Trichinella spp. exposure in wild boar and Iberian domestic pigs from Mediterranean ecosystems of southwestern ... -
The Sigma Class Glutathione Transferase from the Liver Fluke Fasciola hepatica
LaCourse, E. James; Perally, Samirah; Morphew, Russell M.; Moxon, Joseph V.; Prescott, Mark; Dowling, David J.; O'Neill, Sandra M.; Kipar, Anja; Hetzel, Udo; Hoey, Elizabeth; Brophy, Peter M.; Pérez, José; Zafra Leva, Rafael; Buffoni Perazzo, Leandro (Public Library Of Science (PLOS), 2012)Background: Liver fluke infection of livestock causes economic losses of over US$ 3 billion worldwide per annum. The disease is increasing in livestock worldwide and is a re-emerging human disease. There are currently no ... -
Vaccines against helminth parasites of livestock of economic and/or public health significance (PARAVAC)
Zafra Leva, Rafael; Pérez, José; Escamilla, Alejandro; Buffoni Perazzo, Leandro; Pérez Caballero, Raúl; Redacción TR-UCO (Oficina de Transferencia de Resultados de la Investigación, 2013)El proyecto PARAVAC está financiado por el VII Programa Marco con una aportación de la Comisión Europea de unos 9 millones de euros. El principal objetivo de este proyecto es el desarrollo y comercialización de vacunas ...