Listar Departamento de Bioquímica y Biología Molecular por autor "2f69940f-c90b-49c7-a74f-af4d12a8d61f"
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Alzheimer Identification through DNA Methylation and Artificial Intelligence Techniques
Alfonso Pérez, Gerardo; Caballero-Villarraso, Javier (MDPI, 2021)A nonlinear approach to identifying combinations of CpGs DNA methylation data, as biomarkers for Alzheimer (AD) disease, is presented in this paper. It will be shown that the presented algorithm can substantially reduce ... -
An Entropy Approach to Multiple Sclerosis Identification
Alfonso Pérez, Gerardo; Caballero-Villarraso, Javier (MDPI, 2022)Multiple sclerosis (MS) is a relatively common neurodegenerative illness that frequently causes a large level of disability in patients. While its cause is not fully understood, it is likely due to a combination of genetic ... -
CCR6 as a potential target for therapeutic antibodies for the treatment of inflammatory diseases
Gómez-Melero, Sara; Caballero-Villarraso, Javier (MDPI, 2023)The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved in a wide range of biological processes. When CCR6 binds to its sole ligand CCL20, a signaling network is produced. This pathway is implicated ... -
Development of a High-Throughput Calcium Mobilization Assay for CCR6 Receptor Coupled to Hydrolase Activity Readout
Gómez-Melero, Sara; García-Maceira, Fé I.; García-Maceira, Tania; Luna-Guerrero, Verónica; Montero-Peñalvo, Gracia; Caballero-Villarraso, Javier; Túnez, Isaac; Paz-Rojas, Elier (MDPI, 2022)CCR6 is a chemokine receptor highly implicated in inflammatory diseases and could be a potential therapeutic target; however, no therapeutic agents targeting CCR6 have progressed into clinical evaluation. Development of a ... -
Diagnostic effectiveness of [123I] Ioflupane single photon emission computed tomography (SPECT) in multiple system atrophy
Villena-Salinas, Javier; Ortega-Lozano, Simeón José; Amrani-Raissouni, Tomader; Agüera Morales, Eduardo; Caballero-Villarraso, Javier (MDPI, 2023)Background: Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder that has no curative treatment. Diagnosis is based on a set of criteria established by Gilman (1998 and 2008) and recently updated ... -
Extra-Virgin Olive Oil Modifies the Changes Induced in Non-Nervous Organs and Tissues by Experimental Autoimmune Encephalomyelitis Models
Conde, Cristina; Escribano, Begoña M.; Luque, Evelio; Feijóo, Montserrat; Caballero-Villarraso, Javier; Valdelvira, Manuel E.; Ochoa Sepúlveda, Juan J.; Lillo, Rafael; Paz, Elier; Santamaría, Abel; Agüera, Eduardo; Túnez, Isaac (MDPI, 2019)This study reveals the existence of oxidative stress (reactive oxygen species (ROS)) in non-nervous organs and tissues in multiple sclerosis (MS) by means of a model of experimental autoimmune encephalomyelitis (EAE) in ... -
Follow-up findings in multiple system atrophy from [123I]Ioflupane Single-Photon Emission Computed Tomography (SPECT): a prospective study
Villena-Salinas, Javier; Ortega-Lozano, Simeón José; Amrani-Raissouni, Tomader; Agüera, Eduardo; Caballero-Villarraso, Javier (MDPI, 2023)Background: Multiple system atrophy (MSA) is subdivided into two types: MSA-P (parkinsonian) and MSA-C (cerebellar). Brain SPECT allows for the detection of nigrostriatal involvement, even in the early stages. To date, the ... -
Prevalence of active primitive reflexes and craniosacral blocks in apparently healthy children and relationships with neurodevelopment disturbances
León-Bravo, Gema; Cantarero, Irene; Caballero-Villarraso, Javier (MDPI, 2023)Background: In healthy children, the frequency of the anomalous persistence of primitive reflexes (PRs) and craniosacral blocks (CBs) is unknown, as well as their impact on neurodevelopment, behaviour disorders and related ...