Listar por autor "8ba8db5f-bbf8-49eb-ac29-5c556cdeb9b4"

Mostrando ítems 1-11 de 11

    • Caloric Intake in Renal Patients: Repercussions on Mineral Metabolism 

      Vidal, Ángela; Ríos, Rafael; Pineda, Carmen; López, Ignacio; Raya, Ana I.; Aguilera Tejero, Escolástico; Rodríguez, Mariano (MDPI, 2020)
      The aim of this paper is to review current knowledge about how calorie intake influences mineral metabolism focussing on four aspects of major interest for the renal patient: (a) phosphate (P) handling, (b) fibroblast ...

    • Chronic Vitamin D Intoxication in Captive Iberian Lynx (Lynx pardinus) 

      López, Ignacio; Pineda Martos, Carmen María; Muñoz, Luis; Raya, Ana I.; López, Guillermo; Aguilera Tejero, Escolástico (Public Library of Science, 2016)
      To document the biochemical and pathologic features of vitamin D intoxication in lynx and to characterize mineral metabolism in healthy lynx, blood samples were obtained from 40 captive lynx that had been receiving ...

    • Energy-dense diets increase FGF23, lead to phosphorus retention and promote vascular calcifications in rats 

      Raya, Ana I.; Ríos, Rafael; Pineda Martos, Carmen María; Rodríguez-Ortiz, Maria E.; Díez, Elisa; Almadén Peña, Yolanda; Muñoz-Castañeda, Juan R.; Rodríguez, Mariano; Aguilera Tejero, Escolástico; López, Ignacio (Nature.com, 2016)
      Rats with normal renal function (Experiment 1, n = 12) and uninephrectomized (1/2Nx) rats (Experiment 2, n = 12) were fed diets with normal P (NP) and either normal (NF) or high fat (HF). Rats with intact renal function ...

    • Hypocaloric Diet Prevents the Decrease in FGF21 Elicited by High Phosphorus Intake 

      Pineda Martos, Carmen María; Ríos, Rafael; Raya, Ana I.; Rodríguez, Mariano; Aguilera Tejero, Escolástico; López, Ignacio (MDPI, 2018)
      The effect of dietary phosphorus (P) on fibroblast growth factor 21 (FGF21)/ -klotho axis was investigated in rats that were fed diets with: Normal (NP) or high P (HP) and either normal (NC), high (HC) or low calories ...

    • Increased 1,25(OH)2-Vitamin D Concentrations after Energy Restriction Are Associated with Changes in Skeletal Muscle Phenotype 

      Vidal, Ángela; Ríos, Rafael; Pineda, Carmen; López, Ignacio; Raya, Ana I.; Aguilera Tejero, Escolástico; López Rivero, J.L. (MDPI, 2021)
      The influence of energy restriction (ER) on muscle is controversial, and the mechanisms are not well understood. To study the effect of ER on skeletal muscle phenotype and the influence of vitamin D, rats (n = 34) were fed ...

    • Magnesium Inhibits Wnt/β-Catenin Activity and Reverses the Osteogenic Transformation of Vascular Smooth Muscle Cells 

      Montes de Oca, Addy; Guerrero Pavón, Fátima; Martínez-Moreno, Julio M.; Madueño, Juan A.; Herencia, Carmen; Peralta, Alan; Almadén Peña, Yolanda; López, Ignacio; Aguilera Tejero, Escolástico; Gundlach, Kristina; Büchel, Janine; Peter, Mirjam E.; Passlick-Deetjen, Jutta; Rodríguez Portillo, Mariano; Muñoz-Castañeda, Juan R. (Public Library of Science, 2014)
      Magnesium reduces vascular smooth muscle cell (VSMC) calcification in vitro but the mechanism has not been revealed so far. This work used only slightly increased magnesium levels and aimed at determining: a) whether ...

    • Oral Acid Load Down-Regulates Fibroblast Growth Factor 23 

      Vidal, Ángela; Pineda, Carmen; Raya, Ana I.; Ríos, Rafael; Espartero, Azahara; Muñoz-Castañeda, Juan R.; Rodríguez, Mariano; Aguilera Tejero, Escolástico; López, Ignacio (MDPI, 2022)
      Increased dietary acid load has a negative impact on health, particularly when renal function is compromised. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that is elevated during renal failure. The ...

    • Phosphorus restriction does not prevent the increase in fibroblast growth factor 23 elicited by high fat diet 

      Ríos, Rafael; Pineda Martos, Carmen María; López, Ignacio; Muñoz-Castañeda, Juan R.; Rodríguez, Mariano; Aguilera Tejero, Escolástico; Raya, Ana I. (Public Library of Science, 2018)
      This study was designed to evaluate the influence of phosphorus (P) restriction on the dele- terious effects of high fat diets on mineral metabolism. Twenty-four rats were allotted to 3 groups (n ...

    • TGF-β Prevents Phosphate-Induced Osteogenesis through Inhibition of BMP and Wnt/β-Catenin Pathways 

      Guerrero Pavón, Fátima; Herencia, Carmen; Almadén Peña, Yolanda; Martínez-Moreno, Julio M.; Montes de Oca, Addy; Rodríguez-Ortiz, Maria E.; Díaz Tocados, Juan Manuel; Florio, Mónica; López, Ignacio; Richards, William G.; Rodríguez Portillo, Mariano; Aguilera Tejero, Escolástico; Muñoz-Castañeda, Juan R. (Public Library of Science, 2014)
      Background: Transforming growth factor-b (TGF-b) is a key cytokine during differentiation of mesenchymal stem cells (MSC) into vascular smooth muscle cells (VSMC). High phosphate induces a phenotypic transformation of ...

    • Treatment of canine leishmaniasis with marbofloxacin in dogs with renal disease 

      Pineda Martos, Carmen María; Aguilera Tejero, Escolástico; Morales, María C.; Belinchón-Lorenzo, Silvia; Gómez-Nieto, Luis C.; García, Pablo; Martínez-Moreno, Julio M.; Rodríguez-Ortiz, Maria E.; López, Ignacio (Public Library of Science, 2017)
      Treatment of canine leishmaniasis (CanL) represents a challenge. Due to the high prevalence of renal disease associated to CanL, it is important to find an effective drug that does not damage the kidneys. Marbofloxacin ...

    • Vitamin E protects against extraskeletal calcification in uremic rats fed high fat diets 

      Ríos, Rafael; Raya, Ana I.; Pineda Martos, Carmen María; Rodríguez, Mariano; López, Ignacio; Aguilera Tejero, Escolástico (Biomed Central, 2017)
      Background: High fat diets are implicated in the pathogenesis of metabolic syndrome, obesity and renal disease. Previous studies have revealed that high fat diets promote vascular calcification in uremic rats. Moreover, ...