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Neoflavonoids as Inhibitors of HIV-1 Replication by Targeting the Tat and NF-kB Pathways
dc.contributor.author | Olmedo, Dionisio | |
dc.contributor.author | López-Pérez, José L. | |
dc.contributor.author | Olmo, Esther del | |
dc.contributor.author | Bedoya, Luis M. | |
dc.contributor.author | Sancho, Rocío | |
dc.contributor.author | Alcamí, José | |
dc.contributor.author | Muñoz, Eduardo | |
dc.contributor.author | San Feliciano, Arturo | |
dc.contributor.author | Gupta, Mahabir P. | |
dc.date.accessioned | 2017-11-07T09:15:45Z | |
dc.date.available | 2017-11-07T09:15:45Z | |
dc.date.issued | 2017 | |
dc.identifier.uri | http://hdl.handle.net/10396/15326 | |
dc.description.abstract | Twenty-eight neoflavonoids have been prepared and evaluated in vitro against HIV-1. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase reporter gene. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Seven 4-phenylchromen-2-one derivatives showed HIV transcriptional inhibitory activity but only the phenylchrome-2-one 10 inhibited NF- B and displayed anti-Tat activity simultaneously. Compounds 10, 14, and 25, inhibited HIV replication in both targets at concentrations <25 M. The assays of these synthetic 4-phenylchromen-2-ones may aid in the investigation of some aspects of the anti-HIV activity of such compounds and could serve as a scaffold for designing better anti-HIV compounds, which may lead to a potential anti-HIV therapeutic drug | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.source | Molecules 22(2), 321 (2017) | es_ES |
dc.subject | Neoflavonoids | es_ES |
dc.subject | 4-phenyl-chromen-one | es_ES |
dc.subject | AIDS | es_ES |
dc.subject | Tat protein | es_ES |
dc.subject | NF-kB inhibition | es_ES |
dc.subject | Anti-HIV activity | es_ES |
dc.title | Neoflavonoids as Inhibitors of HIV-1 Replication by Targeting the Tat and NF-kB Pathways | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://dx.doy.org/10.3390/molecules22020321 | es_ES |
dc.relation.projectID | Gobierno de España. PI16/CIII/034 | es_ES |
dc.relation.projectID | Gobierno de España. RD16CIII/0002/0001 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |