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dc.contributor.authorMarín, Carmen
dc.contributor.authorYubero-Serrano, Elena M.
dc.contributor.authorPérez-Jiménez, Francisco
dc.contributor.authorLópez-Miranda, José
dc.date.accessioned2017-11-09T11:41:53Z
dc.date.available2017-11-09T11:41:53Z
dc.date.issued2013
dc.identifier.urihttp://hdl.handle.net/10396/15393
dc.description.abstractAging is a condition which favors the development of atherosclerosis, which has been associated with a breakdown in repair processes that occurs in response to cell damage. The dysregulation of the biological systems associated with aging are produced partly through damage which accumulates over time. One major source of this injury is oxidative stress, which can impair biological structures and the mechanisms by which they are repaired. These mechanisms are based on the pathogenesis of endothelial dysfunction, which in turn is associated with cardiovascular disease, carcinogenesis and aging. The dependent dysfunction of aging has been correlated with a reduction in the number and/or functional activity of endothelial progenitor cells, which could hinder the repair and regeneration of the endothelium. In addition, aging, inflammation and oxidative stress are endogenous factors that cause telomere shortening, which is dependent on oxidative cell damage. Moreover, telomere length correlates with lifestyle and the consumption of a healthy diet. Thus, diseases associated with aging and age may be caused by the long-term effects of oxidative damage, which are modified by genetic and environmental factors. Considering that diet is a very important source of antioxidants, in this review we will analyze the relationship between oxidative stress, aging, and the mechanisms which may be involved in a higher survival rate and a lower incidence of the diseases associated with aging in populations which follow a healthy diet.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceInternational Journal of Molecular Sciences 14, 8869-8889 (2013)es_ES
dc.subjectAginges_ES
dc.subjectOxidative stresses_ES
dc.subjectDietes_ES
dc.subjectTelomereses_ES
dc.subjectEndothelial progenitor celles_ES
dc.titleEndothelial Aging Associated with Oxidative Stress Can Be Modulated by a Healthy Mediterranean Dietes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3390/ijms14058869es_ES
dc.relation.projectIDGobierno de España. AGL2006-01979es_ES
dc.relation.projectIDGobierno de España. AGL2009-12270es_ES
dc.relation.projectIDGobierno de España. SAF07-62005es_ES
dc.relation.projectIDGobierno de España. PI10-02412es_ES
dc.relation.projectIDGobierno de España. PI11-00185es_ES
dc.relation.projectIDJunta de Andalucía. P06-CTS-01425es_ES
dc.relation.projectIDJunta de Andalucía. P06-CTS-5015es_ES
dc.relation.projectIDJunta de Andalucía. AGR922es_ES
dc.relation.projectIDJunta de Andalucía. PI0193/09es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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